Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1390621..1391241 Replicon chromosome
Accession NZ_CP118536
Organism Salmonella enterica subsp. enterica serovar Typhi strain S7

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PWA19_RS06750 Protein ID WP_001280991.1
Coordinates 1390621..1390839 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PWA19_RS06755 Protein ID WP_000344807.1
Coordinates 1390867..1391241 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA19_RS06710 (PWA19_06710) 1385844..1386413 + 570 WP_000779802.1 YbaY family lipoprotein -
PWA19_RS06715 (PWA19_06715) 1386446..1386835 - 390 WP_000961285.1 MGMT family protein -
PWA19_RS06725 (PWA19_06725) 1387066..1388616 - 1551 WP_000213129.1 EAL domain-containing protein -
PWA19_RS06730 (PWA19_06730) 1388841..1389101 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PWA19_RS06735 (PWA19_06735) 1389107..1389247 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PWA19_RS06740 (PWA19_06740) 1389303..1389773 - 471 WP_000136183.1 YlaC family protein -
PWA19_RS06745 (PWA19_06745) 1389891..1390442 - 552 WP_001278793.1 maltose O-acetyltransferase -
PWA19_RS06750 (PWA19_06750) 1390621..1390839 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PWA19_RS06755 (PWA19_06755) 1390867..1391241 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PWA19_RS06760 (PWA19_06760) 1391737..1394886 - 3150 WP_001132507.1 efflux RND transporter permease AcrB -
PWA19_RS06765 (PWA19_06765) 1394909..1396102 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T273153 WP_001280991.1 NZ_CP118536:c1390839-1390621 [Salmonella enterica subsp. enterica serovar Typhi]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT273153 WP_000344807.1 NZ_CP118536:c1391241-1390867 [Salmonella enterica subsp. enterica serovar Typhi]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References