Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 789619..790244 Replicon chromosome
Accession NZ_CP118536
Organism Salmonella enterica subsp. enterica serovar Typhi strain S7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PWA19_RS03810 Protein ID WP_000911334.1
Coordinates 789619..790017 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PWA19_RS03815 Protein ID WP_000557549.1
Coordinates 790017..790244 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWA19_RS03795 (PWA19_03795) 786297..786878 - 582 WP_001244646.1 fimbrial protein -
PWA19_RS03800 (PWA19_03800) 787597..788229 - 633 WP_000835268.1 YfdX family protein -
PWA19_RS03805 (PWA19_03805) 788276..788812 - 537 WP_001038500.1 STM3031 family outer membrane protein -
PWA19_RS03810 (PWA19_03810) 789619..790017 - 399 WP_000911334.1 tRNA(fMet)-specific endonuclease VapC Toxin
PWA19_RS03815 (PWA19_03815) 790017..790244 - 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PWA19_RS03820 (PWA19_03820) 790421..790672 + 252 WP_001540858.1 hypothetical protein -
PWA19_RS03825 (PWA19_03825) 790947..791753 + 807 WP_077905073.1 DUF1460 domain-containing protein -
PWA19_RS03830 (PWA19_03830) 792386..793507 - 1122 WP_000028980.1 hypothetical protein -
PWA19_RS03835 (PWA19_03835) 793609..794064 - 456 WP_223229661.1 hypothetical protein -
PWA19_RS03840 (PWA19_03840) 794147..794350 - 204 WP_000184036.1 hypothetical protein -
PWA19_RS03845 (PWA19_03845) 794354..795073 - 720 WP_000082599.1 Rha family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 780429..797325 16896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.44 Da        Isoelectric Point: 7.7785

>T273150 WP_000911334.1 NZ_CP118536:c790017-789619 [Salmonella enterica subsp. enterica serovar Typhi]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNFAVVEGFISRLEVLDYDTQAAIHT
GQIRTELARKGTPVGSYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT273150 WP_000557549.1 NZ_CP118536:c790244-790017 [Salmonella enterica subsp. enterica serovar Typhi]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References