Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1273582..1274499 Replicon chromosome
Accession NZ_CP118495
Organism Bacillus velezensis strain FC02

Toxin (Protein)


Gene name spoIISA Uniprot ID A0A6A8LGT8
Locus tag PVT72_RS06375 Protein ID WP_003154806.1
Coordinates 1273753..1274499 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag PVT72_RS06370 Protein ID WP_003154807.1
Coordinates 1273582..1273752 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVT72_RS06330 (PVT72_06330) 1268813..1270435 + 1623 WP_003154821.1 pyocin knob domain-containing protein -
PVT72_RS06335 (PVT72_06335) 1270448..1270819 + 372 WP_014304856.1 XkdW family protein -
PVT72_RS06340 (PVT72_06340) 1270825..1271022 + 198 WP_003154819.1 XkdX family protein -
PVT72_RS06345 (PVT72_06345) 1271079..1271840 + 762 WP_003154817.1 hypothetical protein -
PVT72_RS06350 (PVT72_06350) 1271892..1272155 + 264 WP_003154815.1 hemolysin XhlA family protein -
PVT72_RS06355 (PVT72_06355) 1272169..1272432 + 264 WP_003154813.1 phage holin -
PVT72_RS06360 (PVT72_06360) 1272446..1273324 + 879 WP_274799507.1 N-acetylmuramoyl-L-alanine amidase -
PVT72_RS06365 (PVT72_06365) 1273360..1273485 - 126 WP_003154809.1 hypothetical protein -
PVT72_RS06370 (PVT72_06370) 1273582..1273752 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
PVT72_RS06375 (PVT72_06375) 1273753..1274499 - 747 WP_003154806.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PVT72_RS06380 (PVT72_06380) 1274604..1275602 - 999 WP_003154805.1 inorganic phosphate transporter -
PVT72_RS06385 (PVT72_06385) 1275615..1276232 - 618 WP_003154804.1 DUF47 domain-containing protein -
PVT72_RS06390 (PVT72_06390) 1276518..1277834 - 1317 WP_003154801.1 amino acid permease -
PVT72_RS06395 (PVT72_06395) 1278158..1279108 + 951 WP_069013314.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29034.50 Da        Isoelectric Point: 4.6947

>T273134 WP_003154806.1 NZ_CP118495:c1274499-1273753 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT273134 WP_003154807.1 NZ_CP118495:c1273752-1273582 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6A8LGT8

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References