Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1133264..1133826 Replicon chromosome
Accession NZ_CP118494
Organism Roseovarius tolerans strain EL-164

Toxin (Protein)


Gene name parE Uniprot ID A0A0L6CZJ2
Locus tag PVU19_RS05560 Protein ID WP_050661008.1
Coordinates 1133264..1133572 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0L6D0K9
Locus tag PVU19_RS05565 Protein ID WP_050661009.1
Coordinates 1133569..1133826 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVU19_RS05540 1128828..1129367 - 540 WP_050661004.1 NADPH-dependent FMN reductase -
PVU19_RS05545 1129549..1130454 - 906 WP_050661005.1 LysR family transcriptional regulator -
PVU19_RS05550 1130647..1131090 + 444 WP_050661006.1 DUF4399 domain-containing protein -
PVU19_RS05555 1131097..1133124 - 2028 WP_050661007.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
PVU19_RS05560 1133264..1133572 - 309 WP_050661008.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PVU19_RS05565 1133569..1133826 - 258 WP_050661009.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PVU19_RS05570 1133891..1134313 - 423 WP_050661010.1 alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB -
PVU19_RS05575 1134624..1135544 - 921 WP_050661011.1 penicillin-insensitive murein endopeptidase -
PVU19_RS05580 1135526..1136908 - 1383 WP_050661012.1 MFS transporter -
PVU19_RS05585 1136964..1137512 - 549 WP_050661013.1 acyl-CoA thioesterase -
PVU19_RS05590 1137644..1137931 + 288 WP_050661014.1 YggT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(4-67)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11626.12 Da        Isoelectric Point: 6.7176

>T273131 WP_050661008.1 NZ_CP118494:c1133572-1133264 [Roseovarius tolerans]
VTEFRLTRTAVADLDDIWDHSKVTWGEQRAESYVTEIFACFSRAAAAPETGRDRSVFVPGARSLPVGRHLVFYRMVGPDV
VILRVVHERRNWAALSFAYDQD

Download         Length: 309 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9502.57 Da        Isoelectric Point: 4.6677

>AT273131 WP_050661009.1 NZ_CP118494:c1133826-1133569 [Roseovarius tolerans]
MPRNTSVVLSDHFNDFIARAVESGRYASTSDVLRAGLRMLERQEAELEFDRLKATLEEADRQAANGETLDVDLESFLAAK
RKTSA

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L6CZJ2

Antitoxin

Source ID Structure
AlphaFold DB A0A0L6D0K9

References