Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4450109..4451682 Replicon chromosome
Accession NZ_CP118442
Organism Aeromonas caviae strain CYEY0630

Toxin (Protein)


Gene name hipA Uniprot ID A0A2I8R9Y0
Locus tag PVK35_RS21660 Protein ID WP_047437768.1
Coordinates 4450109..4451428 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PVK35_RS21665 Protein ID WP_017410478.1
Coordinates 4451428..4451682 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK35_RS21645 (PVK35_21645) 4446021..4446785 + 765 WP_010672275.1 ATP-binding cassette domain-containing protein -
PVK35_RS21650 (PVK35_21650) 4446817..4447710 + 894 WP_274799378.1 ABC transporter substrate-binding protein -
PVK35_RS21655 (PVK35_21655) 4447707..4449689 + 1983 WP_274798979.1 Fe(3+)-hydroxamate ABC transporter permease FhuB -
PVK35_RS21660 (PVK35_21660) 4450109..4451428 - 1320 WP_047437768.1 type II toxin-antitoxin system HipA family toxin Toxin
PVK35_RS21665 (PVK35_21665) 4451428..4451682 - 255 WP_017410478.1 helix-turn-helix domain-containing protein Antitoxin
PVK35_RS21670 (PVK35_21670) 4452378..4453391 - 1014 WP_000845039.1 class 1 integron integrase IntI1 -
PVK35_RS21675 (PVK35_21675) 4453536..4454033 + 498 WP_001083725.1 trimethoprim-resistant dihydrofolate reductase DfrA12 -
PVK35_RS21680 (PVK35_21680) 4454145..4454435 + 291 WP_001336345.1 DUF1010 domain-containing protein -
PVK35_RS21685 (PVK35_21685) 4454441..4455279 + 839 Protein_3977 AadA family aminoglycoside 3''-O-nucleotidyltransferase -
PVK35_RS21690 (PVK35_21690) 4455396..4455743 + 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
PVK35_RS21695 (PVK35_21695) 4455737..4456576 + 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49536.51 Da        Isoelectric Point: 6.8810

>T273130 WP_047437768.1 NZ_CP118442:c4451428-4450109 [Aeromonas caviae]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9293.62 Da        Isoelectric Point: 7.9834

>AT273130 WP_017410478.1 NZ_CP118442:c4451682-4451428 [Aeromonas caviae]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8R9Y0

Antitoxin

Source ID Structure

References