Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2529843..2531671 Replicon chromosome
Accession NZ_CP118438
Organism Vibrio vulnificus strain 1908-10

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PVE41_RS12105 Protein ID WP_013572329.1
Coordinates 2530310..2531671 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PVE41_RS12100 Protein ID WP_029786578.1
Coordinates 2529843..2530325 (-) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVE41_RS12080 (PVE41_12080) 2525856..2526410 + 555 WP_060532377.1 hypothetical protein -
PVE41_RS12085 (PVE41_12085) 2526412..2527167 + 756 WP_061058291.1 NRDE family protein -
PVE41_RS12090 (PVE41_12090) 2527182..2527619 + 438 WP_011078502.1 YHS domain-containing (seleno)protein -
PVE41_RS12095 (PVE41_12095) 2527662..2529404 + 1743 WP_072610740.1 GNAT family N-acyltransferase -
PVE41_RS12100 (PVE41_12100) 2529843..2530325 - 483 WP_029786578.1 helix-turn-helix transcriptional regulator Antitoxin
PVE41_RS12105 (PVE41_12105) 2530310..2531671 - 1362 WP_013572329.1 type II toxin-antitoxin system HipA family toxin Toxin
PVE41_RS12115 (PVE41_12115) 2532559..2533044 - 486 WP_011078466.1 SsrA-binding protein SmpB -
PVE41_RS12120 (PVE41_12120) 2533160..2533591 + 432 WP_026050324.1 SRPBCC family protein -
PVE41_RS12125 (PVE41_12125) 2533588..2533941 + 354 WP_011078464.1 RnfH family protein -
PVE41_RS12130 (PVE41_12130) 2534037..2534396 - 360 WP_011078463.1 outer membrane protein assembly factor BamE -
PVE41_RS12135 (PVE41_12135) 2534575..2536239 - 1665 WP_045595834.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-385)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-139)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51441.20 Da        Isoelectric Point: 4.8182

>T273127 WP_013572329.1 NZ_CP118438:c2531671-2530310 [Vibrio vulnificus]
MEELTVQAFIRSEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHHDKDDFHAVSLNHPVSFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIEQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPVYDFAPMKADPEGIPRTTKWKAPLEVGGTYDFIGIADTLSDLV
PKEVLLQELEVTASKCIDLKQRLALRGVPEQILEMPAVGLNHISEKLTKWGLL

Download         Length: 1362 bp

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 17535.05 Da        Isoelectric Point: 10.8446

>AT273127 WP_029786578.1 NZ_CP118438:c2530325-2529843 [Vibrio vulnificus]
MGATMNKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLG
ELTQGQALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFGLKVGMLPSSPDVLKSLLIDGEAG

Download         Length: 483 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References