Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4915277..4916958 | Replicon | chromosome |
| Accession | NZ_CP118405 | ||
| Organism | Klebsiella pneumoniae strain F3-2P(2*) | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | J2XCI1 |
| Locus tag | HX883_RS23915 | Protein ID | WP_004146663.1 |
| Coordinates | 4915277..4916194 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | HX883_RS23920 | Protein ID | WP_032418188.1 |
| Coordinates | 4916200..4916958 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HX883_RS23895 (4910583) | 4910583..4912103 | + | 1521 | WP_032418186.1 | sugar ABC transporter ATP-binding protein | - |
| HX883_RS23900 (4912100) | 4912100..4913098 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| HX883_RS23905 (4913129) | 4913129..4914070 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| HX883_RS23910 (4914145) | 4914145..4915152 | + | 1008 | WP_032418187.1 | carbohydrate kinase family protein | - |
| HX883_RS23915 (4915277) | 4915277..4916194 | - | 918 | WP_004146663.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| HX883_RS23920 (4916200) | 4916200..4916958 | - | 759 | WP_032418188.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| HX883_RS23925 (4917044) | 4917044..4917772 | - | 729 | WP_004210017.1 | response regulator transcription factor | - |
| HX883_RS23930 (4918045) | 4918045..4920192 | + | 2148 | WP_077598926.1 | formate dehydrogenase subunit alpha | - |
| HX883_RS23935 (4920189) | 4920189..4920332 | - | 144 | WP_022631365.1 | hypothetical protein | - |
| HX883_RS23940 (4920538) | 4920538..4921224 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34659.10 Da Isoelectric Point: 5.4707
>T273122 WP_004146663.1 NZ_CP118405:c4916194-4915277 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28620.99 Da Isoelectric Point: 10.0001
>AT273122 WP_032418188.1 NZ_CP118405:c4916958-4916200 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPETLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|