Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2673281..2674869 Replicon chromosome
Accession NZ_CP118405
Organism Klebsiella pneumoniae strain F3-2P(2*)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HX883_RS13160 Protein ID WP_004184027.1
Coordinates 2673281..2674603 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag HX883_RS13165 Protein ID WP_004176198.1
Coordinates 2674603..2674869 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX883_RS13145 (2668337) 2668337..2670838 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
HX883_RS13150 (2670826) 2670826..2671830 + 1005 WP_016946380.1 fimbrial protein -
HX883_RS13155 (2671972) 2671972..2673264 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HX883_RS13160 (2673281) 2673281..2674603 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
HX883_RS13165 (2674603) 2674603..2674869 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HX883_RS13170 (2675135) 2675135..2675461 - 327 WP_004215084.1 hydroxyisourate hydrolase -
HX883_RS13175 (2675458) 2675458..2675958 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HX883_RS13180 (2675936) 2675936..2677315 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
HX883_RS13185 (2677661) 2677661..2678815 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
HX883_RS13190 (2678796) 2678796..2679719 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T273118 WP_004184027.1 NZ_CP118405:c2674603-2673281 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT273118 WP_004176198.1 NZ_CP118405:c2674869-2674603 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References