Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1755275..1755865 Replicon chromosome
Accession NZ_CP118405
Organism Klebsiella pneumoniae strain F3-2P(2*)

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HX883_RS08500 Protein ID WP_023341911.1
Coordinates 1755533..1755865 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag HX883_RS08495 Protein ID WP_000288812.1
Coordinates 1755275..1755532 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX883_RS08470 (1751185) 1751185..1751259 + 75 Protein_1658 type II toxin-antitoxin system PemK/MazF family toxin -
HX883_RS08475 (1751610) 1751610..1753358 + 1749 WP_032418698.1 hypothetical protein -
HX883_RS08480 (1753412) 1753412..1753993 + 582 WP_099184326.1 hypothetical protein -
HX883_RS08485 (1754276) 1754276..1754737 + 462 WP_004213450.1 hypothetical protein -
HX883_RS08490 (1754734) 1754734..1754940 + 207 WP_020805021.1 helix-turn-helix transcriptional regulator -
HX883_RS08495 (1755275) 1755275..1755532 + 258 WP_000288812.1 antitoxin Antitoxin
HX883_RS08500 (1755533) 1755533..1755865 + 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HX883_RS08510 (1756187) 1756187..1757623 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
HX883_RS08520 (1757989) 1757989..1759443 - 1455 WP_004148975.1 AMP nucleosidase -
HX883_RS08525 (1759573) 1759573..1759818 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T273113 WP_023341911.1 NZ_CP118405:1755533-1755865 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT273113 WP_000288812.1 NZ_CP118405:1755275-1755532 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References