Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 777946..778603 Replicon chromosome
Accession NZ_CP118405
Organism Klebsiella pneumoniae strain F3-2P(2*)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HX883_RS03850 Protein ID WP_002916310.1
Coordinates 778193..778603 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HX883_RS03845 Protein ID WP_002916312.1
Coordinates 777946..778212 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HX883_RS03820 (773102) 773102..774535 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
HX883_RS03825 (774654) 774654..775382 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HX883_RS03830 (775432) 775432..775743 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HX883_RS03835 (775907) 775907..776566 + 660 WP_002916317.1 hemolysin III family protein -
HX883_RS03840 (776717) 776717..777700 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HX883_RS03845 (777946) 777946..778212 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HX883_RS03850 (778193) 778193..778603 + 411 WP_002916310.1 protein YgfX Toxin
HX883_RS03855 (778610) 778610..779131 - 522 WP_004144730.1 flavodoxin FldB -
HX883_RS03860 (779232) 779232..780128 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HX883_RS03865 (780151) 780151..780864 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HX883_RS03870 (780870) 780870..782603 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T273112 WP_002916310.1 NZ_CP118405:778193-778603 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT273112 WP_002916312.1 NZ_CP118405:777946-778212 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References