Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 92346..92872 Replicon plasmid unnamed1
Accession NZ_CP118399
Organism Klebsiella pneumoniae strain 2020CK-00223

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PWK27_RS26810 Protein ID WP_000323025.1
Coordinates 92346..92633 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag PWK27_RS26815 Protein ID WP_004196370.1
Coordinates 92633..92872 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWK27_RS26785 (PWK27_26785) 87659..87931 - 273 WP_032425552.1 hypothetical protein -
PWK27_RS26790 (PWK27_26790) 88588..89556 - 969 WP_072198477.1 IS5 family transposase -
PWK27_RS26795 (PWK27_26795) 89851..90957 - 1107 Protein_102 IS4-like element IS421 family transposase -
PWK27_RS26800 (PWK27_26800) 91034..91152 - 119 Protein_103 type I toxin-antitoxin system Hok family toxin -
PWK27_RS26805 (PWK27_26805) 91263..92295 + 1033 Protein_104 IS481 family transposase -
PWK27_RS26810 (PWK27_26810) 92346..92633 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PWK27_RS26815 (PWK27_26815) 92633..92872 - 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PWK27_RS26820 (PWK27_26820) 92897..92995 + 99 Protein_107 protein YdfV -
PWK27_RS26825 (PWK27_26825) 93123..93488 + 366 WP_009651956.1 hypothetical protein -
PWK27_RS26830 (PWK27_26830) 93532..94269 + 738 WP_008460272.1 HupE/UreJ family protein -
PWK27_RS26835 (PWK27_26835) 94283..94972 + 690 WP_004196322.1 hypothetical protein -
PWK27_RS26840 (PWK27_26840) 95003..96379 - 1377 Protein_111 chromate efflux transporter -
PWK27_RS26845 (PWK27_26845) 96336..97313 - 978 WP_004196334.1 chromate resistance protein -
PWK27_RS26850 (PWK27_26850) 97343..97535 + 193 Protein_113 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..136334 136334


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T273110 WP_000323025.1 NZ_CP118399:c92633-92346 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT273110 WP_004196370.1 NZ_CP118399:c92872-92633 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References