Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4739692..4740208 Replicon chromosome
Accession NZ_CP118398
Organism Klebsiella pneumoniae strain 2020CK-00223

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag PWK27_RS23475 Protein ID WP_009309309.1
Coordinates 4739692..4739976 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PWK27_RS23480 Protein ID WP_002886901.1
Coordinates 4739966..4740208 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWK27_RS23450 (PWK27_23450) 4735175..4735438 - 264 WP_025368518.1 PTS sugar transporter subunit IIB -
PWK27_RS23455 (PWK27_23455) 4735568..4735741 + 174 WP_002886906.1 hypothetical protein -
PWK27_RS23460 (PWK27_23460) 4735744..4736487 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PWK27_RS23465 (PWK27_23465) 4736844..4738982 + 2139 WP_004222153.1 anaerobic ribonucleoside-triphosphate reductase -
PWK27_RS23470 (PWK27_23470) 4739224..4739688 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PWK27_RS23475 (PWK27_23475) 4739692..4739976 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWK27_RS23480 (PWK27_23480) 4739966..4740208 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PWK27_RS23485 (PWK27_23485) 4740286..4742196 - 1911 WP_004152270.1 PRD domain-containing protein -
PWK27_RS23490 (PWK27_23490) 4742219..4743373 - 1155 WP_021313684.1 lactonase family protein -
PWK27_RS23495 (PWK27_23495) 4743440..4744180 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T273103 WP_009309309.1 NZ_CP118398:c4739976-4739692 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273103 WP_002886901.1 NZ_CP118398:c4740208-4739966 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References