Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2742974..2744562 Replicon chromosome
Accession NZ_CP118398
Organism Klebsiella pneumoniae strain 2020CK-00223

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PWK27_RS13820 Protein ID WP_232553822.1
Coordinates 2742974..2744296 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PWK27_RS13825 Protein ID WP_002904790.1
Coordinates 2744296..2744562 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWK27_RS13805 (PWK27_13805) 2738030..2740531 + 2502 WP_232553821.1 fimbria/pilus outer membrane usher protein -
PWK27_RS13810 (PWK27_13810) 2740519..2741523 + 1005 WP_009308876.1 fimbrial protein -
PWK27_RS13815 (PWK27_13815) 2741665..2742957 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PWK27_RS13820 (PWK27_13820) 2742974..2744296 - 1323 WP_232553822.1 type II toxin-antitoxin system HipA family toxin Toxin
PWK27_RS13825 (PWK27_13825) 2744296..2744562 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PWK27_RS13830 (PWK27_13830) 2744828..2745154 - 327 WP_274759103.1 hydroxyisourate hydrolase -
PWK27_RS13835 (PWK27_13835) 2745151..2745651 - 501 WP_064114890.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PWK27_RS13840 (PWK27_13840) 2745629..2747008 - 1380 WP_104158932.1 nucleobase:cation symporter-2 family protein -
PWK27_RS13845 (PWK27_13845) 2747354..2748508 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PWK27_RS13850 (PWK27_13850) 2748489..2749412 - 924 WP_104159103.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49205.48 Da        Isoelectric Point: 7.5357

>T273099 WP_232553822.1 NZ_CP118398:c2744296-2742974 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLF
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT273099 WP_002904790.1 NZ_CP118398:c2744562-2744296 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References