Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 211408..212147 Replicon chromosome
Accession NZ_CP118398
Organism Klebsiella pneumoniae strain 2020CK-00223

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PWK27_RS01050 Protein ID WP_040226741.1
Coordinates 211662..212147 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag PWK27_RS01045 Protein ID WP_003026799.1
Coordinates 211408..211674 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWK27_RS01035 (PWK27_01035) 208614..209938 + 1325 WP_274759508.1 IS3 family transposase -
PWK27_RS01040 (PWK27_01040) 209999..211146 + 1148 WP_232553700.1 IS3 family transposase -
PWK27_RS01045 (PWK27_01045) 211408..211674 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
PWK27_RS01050 (PWK27_01050) 211662..212147 + 486 WP_040226741.1 GNAT family N-acetyltransferase Toxin
PWK27_RS01055 (PWK27_01055) 212472..213518 - 1047 WP_004173931.1 IS481-like element ISKpn28 family transposase -
PWK27_RS01060 (PWK27_01060) 213592..213744 + 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
PWK27_RS01065 (PWK27_01065) 213823..214935 + 1113 WP_001300563.1 IS4-like element IS421 family transposase -
PWK27_RS01070 (PWK27_01070) 215395..217013 + 1619 Protein_212 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 209351..215098 5747


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(35-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.44 Da        Isoelectric Point: 10.3370

>T273091 WP_040226741.1 NZ_CP118398:211662-212147 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
LDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT273091 WP_003026799.1 NZ_CP118398:211408-211674 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References