Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 3245439..3246238 Replicon chromosome
Accession NZ_CP118390
Organism Edwardsiella piscicida strain Ep21-8

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag PWJ79_RS14775 Protein ID WP_041692550.1
Coordinates 3245705..3246238 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag PWJ79_RS14770 Protein ID WP_041692549.1
Coordinates 3245439..3245708 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWJ79_RS14735 (PWJ79_14735) 3241018..3241734 + 717 WP_012849890.1 SprT family zinc-dependent metalloprotease -
PWJ79_RS14740 (PWJ79_14740) 3241979..3242518 + 540 WP_012849891.1 transposase DNA-binding-containing protein -
PWJ79_RS14745 (PWJ79_14745) 3242532..3243329 + 798 Protein_2848 IS21 family transposase -
PWJ79_RS14750 (PWJ79_14750) 3243566..3243781 - 216 WP_012849893.1 PapB/FocB family fimbrial expression transcriptional regulator -
PWJ79_RS14755 (PWJ79_14755) 3243793..3244056 - 264 WP_041692548.1 DUF2442 domain-containing protein -
PWJ79_RS14760 (PWJ79_14760) 3244016..3244255 - 240 WP_012849894.1 DUF4160 domain-containing protein -
PWJ79_RS14765 (PWJ79_14765) 3244749..3245345 + 597 WP_071818540.1 helix-turn-helix domain-containing protein -
PWJ79_RS14770 (PWJ79_14770) 3245439..3245708 + 270 WP_041692549.1 DUF1778 domain-containing protein Antitoxin
PWJ79_RS14775 (PWJ79_14775) 3245705..3246238 + 534 WP_041692550.1 GNAT family N-acetyltransferase Toxin
PWJ79_RS14780 (PWJ79_14780) 3246336..3247079 - 744 WP_012849897.1 hypothetical protein -
PWJ79_RS14785 (PWJ79_14785) 3249077..3249328 + 252 Protein_2856 IS21 family transposase -
PWJ79_RS14790 (PWJ79_14790) 3249325..3250107 + 783 WP_012846920.1 IS21-like element ISSen3 family helper ATPase IstB -
PWJ79_RS14795 (PWJ79_14795) 3250212..3251015 + 804 WP_012849899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3203579..3259228 55649
- flank IS/Tn - - 3242532..3243413 881
- flank IS/Tn - - 3249328..3250107 779


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19938.93 Da        Isoelectric Point: 7.0275

>T273090 WP_041692550.1 NZ_CP118390:3245705-3246238 [Edwardsiella piscicida]
MNSGTEFKELSKADHDRDSFDCGEIELNNFIKNFALKHMRVGISKTMVLPATDALPNNKHPICAFYTVAPSSITRNSLPD
DLGKKLPHYPVPVFLLAQLSVHIDNQGDGLGKITLIKALEYLWNVNYFLHAYAVVVDCLNDKAESFYRKYGFETLCSYDG
RVRLFLPMKTVAGLFSD

Download         Length: 534 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9827.37 Da        Isoelectric Point: 7.1662

>AT273090 WP_041692549.1 NZ_CP118390:3245439-3245708 [Edwardsiella piscicida]
MATARLDLRLDPEIKAKAEKASALLGLKTLTEYIVHIVDNDAKRVIAAHESMALPNDIFDQFMNACEQAKEPNSALKSAL
SFTREKGIK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References