Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3093488..3094151 Replicon chromosome
Accession NZ_CP118390
Organism Edwardsiella piscicida strain Ep21-8

Toxin (Protein)


Gene name cptA Uniprot ID A0A411H3S7
Locus tag PWJ79_RS14095 Protein ID WP_034167931.1
Coordinates 3093488..3093904 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID D0ZDY6
Locus tag PWJ79_RS14100 Protein ID WP_012849755.1
Coordinates 3093885..3094151 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWJ79_RS14075 (PWJ79_14075) 3089419..3091152 - 1734 WP_012849750.1 single-stranded-DNA-specific exonuclease RecJ -
PWJ79_RS14080 (PWJ79_14080) 3091157..3091873 - 717 WP_012849751.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PWJ79_RS14085 (PWJ79_14085) 3091901..3092800 - 900 WP_012849752.1 site-specific tyrosine recombinase XerD -
PWJ79_RS14090 (PWJ79_14090) 3092951..3093463 + 513 WP_012849753.1 flavodoxin FldB -
PWJ79_RS14095 (PWJ79_14095) 3093488..3093904 - 417 WP_034167931.1 protein YgfX Toxin
PWJ79_RS14100 (PWJ79_14100) 3093885..3094151 - 267 WP_012849755.1 FAD assembly factor SdhE Antitoxin
PWJ79_RS14105 (PWJ79_14105) 3094505..3095503 + 999 WP_012849756.1 tRNA-modifying protein YgfZ -
PWJ79_RS14110 (PWJ79_14110) 3095546..3096370 - 825 WP_012849757.1 shikimate 5-dehydrogenase -
PWJ79_RS14115 (PWJ79_14115) 3096529..3097401 - 873 WP_012849758.1 nucleoside-specific channel-forming protein Tsx -
PWJ79_RS14120 (PWJ79_14120) 3098010..3098660 + 651 WP_015462279.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16213.03 Da        Isoelectric Point: 11.6049

>T273088 WP_034167931.1 NZ_CP118390:c3093904-3093488 [Edwardsiella piscicida]
VVLWRCNVHVSWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRRIARNRGELQLLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGAPCRRRLWLAADSMSREEWGQLRRTLLDAGDDRA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10318.90 Da        Isoelectric Point: 5.6951

>AT273088 WP_012849755.1 NZ_CP118390:c3094151-3093885 [Edwardsiella piscicida]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLACDDPELFKWLMNQGKPDDADLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H3S7

Antitoxin

Source ID Structure
AlphaFold DB A0A034T2Q8

References