Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 68928..69454 Replicon plasmid unnamed1
Accession NZ_CP118384
Organism Enterobacter hormaechei strain 2020CK-00224

Toxin (Protein)


Gene name relE Uniprot ID A0A7R6HXL1
Locus tag PWH45_RS23975 Protein ID WP_015572079.1
Coordinates 69167..69454 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PWH45_RS23970 Protein ID WP_000534858.1
Coordinates 68928..69167 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWH45_RS23940 (PWH45_23940) 64001..64936 - 936 WP_004118100.1 GlxA family transcriptional regulator -
PWH45_RS23945 (PWH45_23945) 64947..66149 - 1203 WP_015572077.1 MFS transporter -
PWH45_RS23950 (PWH45_23950) 66189..66950 - 762 WP_004118132.1 SDR family NAD(P)-dependent oxidoreductase -
PWH45_RS23955 (PWH45_23955) 66980..67795 - 816 WP_032670836.1 SDR family oxidoreductase -
PWH45_RS23960 (PWH45_23960) 68259..68579 + 321 WP_004197483.1 hypothetical protein -
PWH45_RS23965 (PWH45_23965) 68801..68903 - 103 Protein_75 hypothetical protein -
PWH45_RS23970 (PWH45_23970) 68928..69167 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PWH45_RS23975 (PWH45_23975) 69167..69454 + 288 WP_015572079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PWH45_RS23980 (PWH45_23980) 69526..69684 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
PWH45_RS23985 (PWH45_23985) 70408..70926 + 519 WP_274753234.1 hypothetical protein -
PWH45_RS23990 (PWH45_23990) 70923..71270 + 348 WP_045325353.1 hypothetical protein -
PWH45_RS23995 (PWH45_23995) 71972..72265 + 294 WP_032670838.1 hypothetical protein -
PWH45_RS24000 (PWH45_24000) 72282..73103 + 822 WP_015572081.1 DUF932 domain-containing protein -
PWH45_RS24005 (PWH45_24005) 73132..73671 - 540 WP_032664846.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..175563 175563


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11209.09 Da        Isoelectric Point: 10.0714

>T273081 WP_015572079.1 NZ_CP118384:69167-69454 [Enterobacter hormaechei]
MAYFLDFDERALKEWRKLGSTVREQLKNKLAEVLESPRIDANKLRGMHDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT273081 WP_000534858.1 NZ_CP118384:68928-69167 [Enterobacter hormaechei]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References