Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3765125..3765924 Replicon chromosome
Accession NZ_CP118383
Organism Enterobacter hormaechei strain 2020CK-00224

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag PWH45_RS17975 Protein ID WP_047745262.1
Coordinates 3765125..3765511 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PWH45_RS17980 Protein ID WP_029504114.1
Coordinates 3765565..3765924 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWH45_RS17950 (PWH45_17950) 3761057..3761428 + 372 WP_047745267.1 hypothetical protein -
PWH45_RS17955 (PWH45_17955) 3761487..3761954 - 468 WP_072204536.1 SymE family type I addiction module toxin -
PWH45_RS17960 (PWH45_17960) 3762255..3763124 + 870 Protein_3507 HNH endonuclease -
PWH45_RS17965 (PWH45_17965) 3763258..3764049 - 792 WP_047745265.1 helix-turn-helix transcriptional regulator -
PWH45_RS17970 (PWH45_17970) 3764193..3765038 - 846 WP_047745264.1 DUF4942 domain-containing protein -
PWH45_RS17975 (PWH45_17975) 3765125..3765511 - 387 WP_047745262.1 TA system toxin CbtA family protein Toxin
PWH45_RS17980 (PWH45_17980) 3765565..3765924 - 360 WP_029504114.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PWH45_RS17985 (PWH45_17985) 3765949..3766170 - 222 WP_047745260.1 DUF987 domain-containing protein -
PWH45_RS17990 (PWH45_17990) 3766184..3766663 - 480 WP_029504112.1 DNA repair protein RadC -
PWH45_RS17995 (PWH45_17995) 3766675..3767124 - 450 WP_047745258.1 antirestriction protein -
PWH45_RS18000 (PWH45_18000) 3767157..3767978 - 822 WP_004192305.1 DUF932 domain-containing protein -
PWH45_RS18005 (PWH45_18005) 3768312..3769262 - 951 WP_047745256.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14402.46 Da        Isoelectric Point: 8.9843

>T273078 WP_047745262.1 NZ_CP118383:c3765511-3765125 [Enterobacter hormaechei]
MQTKLPFMRAASSRPSPVDVWQTLLTCLLEHHYGLTLNDTPFSDELVIQQHIDAGISLADALNFIVEKYELVRTDRPGFS
IREQSPFITAFDILRARKATGLMNRGTYKEVTAITRGQHPQASTSGKR

Download         Length: 387 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13407.32 Da        Isoelectric Point: 7.0371

>AT273078 WP_029504114.1 NZ_CP118383:c3765924-3765565 [Enterobacter hormaechei]
MSKKTTLTTHDISEPWWGLRRSISPCFGARLVQMGNRLHYLADRANFDGQFCDADLRHLDQAFPVLMKQLELMLTSGELN
PRHQHGVTLYAKGLTCEADTLGSHGYVYIAIYPAPVTTE

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References