Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3725490..3726066 Replicon chromosome
Accession NZ_CP118383
Organism Enterobacter hormaechei strain 2020CK-00224

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag PWH45_RS17780 Protein ID WP_015572580.1
Coordinates 3725779..3726066 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag PWH45_RS17775 Protein ID WP_017694570.1
Coordinates 3725490..3725792 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWH45_RS17755 (PWH45_17755) 3721787..3722332 + 546 WP_006810254.1 YfaZ family outer membrane protein -
PWH45_RS17760 (PWH45_17760) 3722508..3723878 - 1371 WP_047745287.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PWH45_RS17765 (PWH45_17765) 3724032..3724784 + 753 WP_047745285.1 AraC family transcriptional regulator -
PWH45_RS17770 (PWH45_17770) 3724823..3725461 + 639 WP_047736941.1 LysE family translocator -
PWH45_RS17775 (PWH45_17775) 3725490..3725792 - 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
PWH45_RS17780 (PWH45_17780) 3725779..3726066 - 288 WP_015572580.1 BrnT family toxin Toxin
PWH45_RS17785 (PWH45_17785) 3726236..3727507 + 1272 WP_047745284.1 DUF445 domain-containing protein -
PWH45_RS17790 (PWH45_17790) 3727504..3728580 - 1077 WP_015572578.1 DUF2955 domain-containing protein -
PWH45_RS17795 (PWH45_17795) 3728570..3729637 - 1068 WP_116293634.1 HlyD family secretion protein -
PWH45_RS17800 (PWH45_17800) 3729634..3730104 - 471 WP_015572576.1 MarR family transcriptional regulator -
PWH45_RS17805 (PWH45_17805) 3730254..3730949 - 696 WP_032647138.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T273077 WP_015572580.1 NZ_CP118383:c3726066-3725779 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT273077 WP_017694570.1 NZ_CP118383:c3725792-3725490 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References