Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3301525..3302182 Replicon chromosome
Accession NZ_CP118383
Organism Enterobacter hormaechei strain 2020CK-00224

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PWH45_RS15740 Protein ID WP_274751622.1
Coordinates 3301525..3301935 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PWH45_RS15745 Protein ID WP_003863437.1
Coordinates 3301916..3302182 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PWH45_RS15720 (PWH45_15720) 3297523..3299256 - 1734 WP_017382886.1 single-stranded-DNA-specific exonuclease RecJ -
PWH45_RS15725 (PWH45_15725) 3299262..3299975 - 714 WP_047745230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PWH45_RS15730 (PWH45_15730) 3300004..3300900 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PWH45_RS15735 (PWH45_15735) 3301002..3301523 + 522 WP_015571793.1 flavodoxin FldB -
PWH45_RS15740 (PWH45_15740) 3301525..3301935 - 411 WP_274751622.1 protein YgfX Toxin
PWH45_RS15745 (PWH45_15745) 3301916..3302182 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PWH45_RS15750 (PWH45_15750) 3302477..3303457 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
PWH45_RS15755 (PWH45_15755) 3303569..3304228 - 660 WP_047745228.1 hemolysin III family protein -
PWH45_RS15760 (PWH45_15760) 3304495..3305226 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
PWH45_RS15765 (PWH45_15765) 3305343..3306776 + 1434 WP_047745227.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16335.23 Da        Isoelectric Point: 11.4775

>T273076 WP_274751622.1 NZ_CP118383:c3301935-3301525 [Enterobacter hormaechei]
VVLWQSDLRLSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT273076 WP_003863437.1 NZ_CP118383:c3302182-3301916 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References