Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2578866..2579605 Replicon chromosome
Accession NZ_CP118332
Organism Klebsiella aerogenes strain IIIF7SW-P1

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag HZS33_RS12395 Protein ID WP_015705365.1
Coordinates 2579120..2579605 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag HZS33_RS12390 Protein ID WP_015705366.1
Coordinates 2578866..2579132 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS33_RS12365 (2574201) 2574201..2574788 + 588 WP_047048982.1 hypothetical protein -
HZS33_RS12370 (2574785) 2574785..2576104 + 1320 WP_047076454.1 ATP-binding protein -
HZS33_RS12375 (2576104) 2576104..2576721 + 618 WP_020078884.1 response regulator -
HZS33_RS12380 (2576817) 2576817..2577314 + 498 WP_047076455.1 heme-binding protein -
HZS33_RS12385 (2577358) 2577358..2578593 - 1236 WP_020078885.1 MFS transporter -
HZS33_RS12390 (2578866) 2578866..2579132 + 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
HZS33_RS12395 (2579120) 2579120..2579605 + 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
HZS33_RS12400 (2579677) 2579677..2581293 + 1617 WP_015705364.1 FAD-NAD(P)-binding protein -
HZS33_RS12405 (2581412) 2581412..2582512 + 1101 WP_047076456.1 NADH:flavin oxidoreductase/NADH oxidase -
HZS33_RS12410 (2582569) 2582569..2582727 - 159 WP_002903230.1 YqaE/Pmp3 family membrane protein -
HZS33_RS12415 (2582988) 2582988..2584058 + 1071 WP_020078888.1 mannonate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T273067 WP_015705365.1 NZ_CP118332:2579120-2579605 [Klebsiella aerogenes]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT273067 WP_015705366.1 NZ_CP118332:2578866-2579132 [Klebsiella aerogenes]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References