Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837549..838206 Replicon chromosome
Accession NZ_CP118332
Organism Klebsiella aerogenes strain IIIF7SW-P1

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag HZS33_RS04090 Protein ID WP_015369792.1
Coordinates 837796..838206 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag HZS33_RS04085 Protein ID WP_015369791.1
Coordinates 837549..837815 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS33_RS04060 (832776) 832776..834209 - 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -
HZS33_RS04065 (834329) 834329..835057 - 729 WP_179373275.1 MurR/RpiR family transcriptional regulator -
HZS33_RS04070 (835108) 835108..835419 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
HZS33_RS04075 (835584) 835584..836243 + 660 WP_008806429.1 hemolysin III family protein -
HZS33_RS04080 (836342) 836342..837325 - 984 WP_015369790.1 tRNA-modifying protein YgfZ -
HZS33_RS04085 (837549) 837549..837815 + 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
HZS33_RS04090 (837796) 837796..838206 + 411 WP_015369792.1 protein YgfX Toxin
HZS33_RS04095 (838214) 838214..838735 - 522 WP_015369793.1 flavodoxin FldB -
HZS33_RS04100 (838836) 838836..839732 + 897 WP_045414365.1 site-specific tyrosine recombinase XerD -
HZS33_RS04105 (839755) 839755..840468 + 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HZS33_RS04110 (840474) 840474..842207 + 1734 WP_032715785.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T273062 WP_015369792.1 NZ_CP118332:837796-838206 [Klebsiella aerogenes]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT273062 WP_015369791.1 NZ_CP118332:837549-837815 [Klebsiella aerogenes]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References