Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 264700..265331 Replicon chromosome
Accession NZ_CP118332
Organism Klebsiella aerogenes strain IIIF7SW-P1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag HZS33_RS01210 Protein ID WP_015703741.1
Coordinates 264700..264975 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag HZS33_RS01215 Protein ID WP_015703740.1
Coordinates 264972..265331 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HZS33_RS01190 (259928) 259928..260263 + 336 WP_015703743.1 universal stress protein UspB -
HZS33_RS01195 (260329) 260329..261825 - 1497 WP_015369272.1 inorganic phosphate transporter PitA -
HZS33_RS01200 (262056) 262056..263249 + 1194 WP_045359198.1 NAD(P)/FAD-dependent oxidoreductase -
HZS33_RS01205 (263290) 263290..264303 - 1014 WP_015369274.1 magnesium transporter -
HZS33_RS01210 (264700) 264700..264975 + 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
HZS33_RS01215 (264972) 264972..265331 + 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HZS33_RS01220 (265359) 265359..265760 - 402 WP_020077744.1 nickel-responsive transcriptional regulator NikR -
HZS33_RS01225 (265748) 265748..266539 - 792 WP_032715259.1 nickel import ATP-binding protein NikE -
HZS33_RS01230 (266536) 266536..267300 - 765 WP_032713129.1 nickel import ATP-binding protein NikD -
HZS33_RS01235 (267300) 267300..268133 - 834 WP_015369278.1 nickel ABC transporter permease subunit NikC -
HZS33_RS01240 (268130) 268130..269074 - 945 WP_047076095.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T273060 WP_015703741.1 NZ_CP118332:264700-264975 [Klebsiella aerogenes]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT273060 WP_015703740.1 NZ_CP118332:264972-265331 [Klebsiella aerogenes]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References