Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4305443..4306050 Replicon chromosome
Accession NZ_CP118279
Organism Enterobacter hormaechei strain LG3

Toxin (Protein)


Gene name hicA Uniprot ID A0A4Q4AAS0
Locus tag LNGFDJGK_RS20540 Protein ID WP_057979982.1
Coordinates 4305865..4306050 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LNGFDJGK_RS20535 Protein ID WP_045337117.1
Coordinates 4305443..4305850 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNGFDJGK_RS20520 (LNGFDJGK_04065) 4302186..4303439 + 1254 WP_015572749.1 valine--pyruvate transaminase -
LNGFDJGK_RS20525 (LNGFDJGK_04066) 4303447..4303902 - 456 WP_045337119.1 4Fe-4S dicluster domain-containing protein -
LNGFDJGK_RS20530 (LNGFDJGK_04067) 4304363..4305439 + 1077 WP_023323870.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
LNGFDJGK_RS20535 (LNGFDJGK_04068) 4305443..4305850 - 408 WP_045337117.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LNGFDJGK_RS20540 4305865..4306050 - 186 WP_057979982.1 type II toxin-antitoxin system HicA family toxin Toxin
LNGFDJGK_RS20545 (LNGFDJGK_04069) 4306296..4307834 - 1539 WP_006808612.1 aldehyde dehydrogenase AldB -
LNGFDJGK_RS20550 (LNGFDJGK_04070) 4308001..4308885 + 885 WP_045337115.1 ROK family protein -
LNGFDJGK_RS20555 (LNGFDJGK_04071) 4308889..4310727 - 1839 WP_045337113.1 selenocysteine-specific translation elongation factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6852.08 Da        Isoelectric Point: 11.5191

>T273059 WP_057979982.1 NZ_CP118279:c4306050-4305865 [Enterobacter hormaechei]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15263.24 Da        Isoelectric Point: 4.4217

>AT273059 WP_045337117.1 NZ_CP118279:c4305850-4305443 [Enterobacter hormaechei]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPDMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Q4AAS0

Antitoxin

Source ID Structure

References