Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3673240..3673897 Replicon chromosome
Accession NZ_CP118279
Organism Enterobacter hormaechei strain LG3

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag LNGFDJGK_RS17470 Protein ID WP_045337133.1
Coordinates 3673240..3673650 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LNGFDJGK_RS17475 Protein ID WP_003863437.1
Coordinates 3673631..3673897 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNGFDJGK_RS17450 (LNGFDJGK_03456) 3669238..3670971 - 1734 WP_023314793.1 single-stranded-DNA-specific exonuclease RecJ -
LNGFDJGK_RS17455 (LNGFDJGK_03457) 3670977..3671690 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LNGFDJGK_RS17460 (LNGFDJGK_03458) 3671719..3672615 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
LNGFDJGK_RS17465 (LNGFDJGK_03459) 3672717..3673238 + 522 WP_003863440.1 flavodoxin FldB -
LNGFDJGK_RS17470 (LNGFDJGK_03460) 3673240..3673650 - 411 WP_045337133.1 protein YgfX Toxin
LNGFDJGK_RS17475 (LNGFDJGK_03461) 3673631..3673897 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LNGFDJGK_RS17480 (LNGFDJGK_03462) 3674192..3675172 + 981 WP_022649306.1 tRNA-modifying protein YgfZ -
LNGFDJGK_RS17485 (LNGFDJGK_03464) 3675258..3675917 - 660 WP_003863433.1 hemolysin III family protein -
LNGFDJGK_RS17490 (LNGFDJGK_03465) 3676184..3676915 + 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
LNGFDJGK_RS17495 (LNGFDJGK_03466) 3677032..3678465 + 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16289.15 Da        Isoelectric Point: 11.4775

>T273058 WP_045337133.1 NZ_CP118279:c3673650-3673240 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWVLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT273058 WP_003863437.1 NZ_CP118279:c3673897-3673631 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References