Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA(toxin)
Location 2970052..2971835 Replicon chromosome
Accession NZ_CP118279
Organism Enterobacter hormaechei strain LG3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LNGFDJGK_RS14215 Protein ID WP_023314540.1
Coordinates 2970052..2971401 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A837FFV9
Locus tag LNGFDJGK_RS14220 Protein ID WP_003859317.1
Coordinates 2971398..2971835 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNGFDJGK_RS14190 (LNGFDJGK_02807) 2965875..2966810 - 936 WP_045337652.1 tRNA dihydrouridine(16) synthase DusC -
LNGFDJGK_RS14195 (LNGFDJGK_02808) 2966979..2967374 + 396 WP_003859308.1 CidA/LrgA family protein -
LNGFDJGK_RS14200 (LNGFDJGK_02809) 2967371..2968066 + 696 WP_003859310.1 CidB/LrgB family autolysis modulator -
LNGFDJGK_RS14205 (LNGFDJGK_02810) 2968195..2969079 + 885 WP_003859312.1 cytidine deaminase -
LNGFDJGK_RS14210 (LNGFDJGK_02811) 2969207..2969917 + 711 WP_275777980.1 outer membrane permeability protein SanA -
LNGFDJGK_RS14215 (LNGFDJGK_02812) 2970052..2971401 + 1350 WP_023314540.1 HipA domain-containing protein Toxin
LNGFDJGK_RS14220 2971398..2971835 + 438 WP_003859317.1 helix-turn-helix transcriptional regulator Antitoxin
LNGFDJGK_RS14225 (LNGFDJGK_02813) 2971874..2972884 - 1011 WP_003859318.1 galactose/methyl galactoside ABC transporter permease MglC -
LNGFDJGK_RS14230 (LNGFDJGK_02814) 2972900..2974420 - 1521 WP_003859320.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
LNGFDJGK_RS14235 (LNGFDJGK_02815) 2974500..2975498 - 999 WP_045337654.1 galactose/glucose ABC transporter substrate-binding protein MglB -
LNGFDJGK_RS14240 (LNGFDJGK_02816) 2975794..2976816 - 1023 WP_045337656.1 HTH-type transcriptional regulator GalS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51137.78 Da        Isoelectric Point: 4.6562

>T273056 WP_023314540.1 NZ_CP118279:2970052-2971401 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHELNAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Download         Length: 1350 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 16185.64 Da        Isoelectric Point: 10.5154

>AT273056 WP_003859317.1 NZ_CP118279:2971398-2971835 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A837FFV9

References