Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2191697..2192436 Replicon chromosome
Accession NZ_CP118279
Organism Enterobacter hormaechei strain LG3

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag LNGFDJGK_RS10495 Protein ID WP_003857133.1
Coordinates 2191697..2192182 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A927HKN6
Locus tag LNGFDJGK_RS10500 Protein ID WP_045336276.1
Coordinates 2192170..2192436 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNGFDJGK_RS10475 (LNGFDJGK_02083) 2187851..2188609 - 759 WP_023314159.1 trans-aconitate 2-methyltransferase -
LNGFDJGK_RS10480 (LNGFDJGK_02084) 2188694..2189278 - 585 WP_045336272.1 GDP-mannose pyrophosphatase -
LNGFDJGK_RS10485 (LNGFDJGK_02085) 2189365..2190123 + 759 WP_045336273.1 DeoR/GlpR family DNA-binding transcription regulator -
LNGFDJGK_RS10490 (LNGFDJGK_02086) 2190228..2191520 + 1293 WP_045336275.1 glycosyl hydrolase family 28 protein -
LNGFDJGK_RS10495 (LNGFDJGK_02087) 2191697..2192182 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
LNGFDJGK_RS10500 (LNGFDJGK_02088) 2192170..2192436 - 267 WP_045336276.1 DUF1778 domain-containing protein Antitoxin
LNGFDJGK_RS10505 (LNGFDJGK_02089) 2192500..2193429 - 930 WP_045336278.1 LysR family transcriptional regulator -
LNGFDJGK_RS10510 (LNGFDJGK_02090) 2193559..2194947 + 1389 WP_045336280.1 MFS transporter -
LNGFDJGK_RS10515 (LNGFDJGK_02091) 2194969..2195964 - 996 WP_045336282.1 DUF2891 domain-containing protein -
LNGFDJGK_RS10520 (LNGFDJGK_02092) 2195974..2196960 - 987 WP_045336284.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T273051 WP_003857133.1 NZ_CP118279:c2192182-2191697 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10032.46 Da        Isoelectric Point: 4.4857

>AT273051 WP_045336276.1 NZ_CP118279:c2192436-2192170 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWGV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure

References