Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1034913..1035533 Replicon chromosome
Accession NZ_CP118279
Organism Enterobacter hormaechei strain LG3

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag LNGFDJGK_RS04915 Protein ID WP_015571250.1
Coordinates 1034913..1035131 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag LNGFDJGK_RS04920 Protein ID WP_006809850.1
Coordinates 1035159..1035533 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNGFDJGK_RS04885 (LNGFDJGK_00975) 1030925..1031185 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
LNGFDJGK_RS04890 (LNGFDJGK_00976) 1031188..1031328 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LNGFDJGK_RS04895 (LNGFDJGK_00977) 1031325..1032035 - 711 WP_045337215.1 GNAT family protein -
LNGFDJGK_RS04900 (LNGFDJGK_00978) 1032137..1033597 + 1461 WP_022650494.1 PLP-dependent aminotransferase family protein -
LNGFDJGK_RS04905 (LNGFDJGK_00979) 1033569..1034036 - 468 WP_022650495.1 YlaC family protein -
LNGFDJGK_RS04910 (LNGFDJGK_00980) 1034153..1034704 - 552 WP_022650496.1 maltose O-acetyltransferase -
LNGFDJGK_RS04915 (LNGFDJGK_00981) 1034913..1035131 - 219 WP_015571250.1 HHA domain-containing protein Toxin
LNGFDJGK_RS04920 (LNGFDJGK_00982) 1035159..1035533 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
LNGFDJGK_RS04925 (LNGFDJGK_00983) 1036043..1039189 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
LNGFDJGK_RS04930 (LNGFDJGK_00984) 1039212..1040405 - 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T273050 WP_015571250.1 NZ_CP118279:c1035131-1034913 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT273050 WP_006809850.1 NZ_CP118279:c1035533-1035159 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References