Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4642613..4643126 Replicon chromosome
Accession NZ_CP118278
Organism Klebsiella quasipneumoniae strain IIIF3SW-P1

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag HW458_RS22420 Protein ID WP_017900571.1
Coordinates 4642613..4642894 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HW458_RS22425 Protein ID WP_002886901.1
Coordinates 4642884..4643126 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW458_RS22410 (4639572) 4639572..4641710 + 2139 WP_135722534.1 anaerobic ribonucleoside-triphosphate reductase -
HW458_RS22415 (4642145) 4642145..4642609 + 465 WP_032456904.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HW458_RS22420 (4642613) 4642613..4642894 - 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW458_RS22425 (4642884) 4642884..4643126 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HW458_RS22430 (4643204) 4643204..4645114 - 1911 WP_205608966.1 PRD domain-containing protein -
HW458_RS22435 (4645137) 4645137..4646288 - 1152 WP_023319593.1 lactonase family protein -
HW458_RS22440 (4646355) 4646355..4647095 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T273047 WP_017900571.1 NZ_CP118278:c4642894-4642613 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273047 WP_002886901.1 NZ_CP118278:c4643126-4642884 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663BE04

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References