Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2564058..2565646 Replicon chromosome
Accession NZ_CP118278
Organism Klebsiella quasipneumoniae strain IIIF3SW-P1

Toxin (Protein)


Gene name hipA Uniprot ID A0A246AZS4
Locus tag HW458_RS12420 Protein ID WP_017900381.1
Coordinates 2564058..2565380 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag HW458_RS12425 Protein ID WP_004205921.1
Coordinates 2565380..2565646 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW458_RS12385 (2559139) 2559139..2559357 + 219 WP_002904808.1 ParD-like family protein -
HW458_RS12390 (2559338) 2559338..2560120 + 783 WP_205608546.1 type I methionyl aminopeptidase -
HW458_RS12395 (2560390) 2560390..2561505 + 1116 WP_194007029.1 serine hydrolase domain-containing protein -
HW458_RS12400 (2561492) 2561492..2561836 + 345 WP_017900383.1 hypothetical protein -
HW458_RS12405 (2561865) 2561865..2562398 + 534 WP_004205916.1 hypothetical protein -
HW458_RS12410 (2562401) 2562401..2562607 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
HW458_RS12415 (2562749) 2562749..2564041 + 1293 WP_017900382.1 glycoside hydrolase family 10 protein -
HW458_RS12420 (2564058) 2564058..2565380 - 1323 WP_017900381.1 type II toxin-antitoxin system HipA family toxin Toxin
HW458_RS12425 (2565380) 2565380..2565646 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HW458_RS12430 (2565929) 2565929..2566255 - 327 WP_017900379.1 hydroxyisourate hydrolase -
HW458_RS12435 (2566252) 2566252..2566752 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HW458_RS12440 (2566730) 2566730..2568109 - 1380 WP_017900377.1 nucleobase:cation symporter-2 family protein -
HW458_RS12445 (2568455) 2568455..2569609 + 1155 WP_032456029.1 FAD-dependent urate hydroxylase HpxO -
HW458_RS12450 (2569590) 2569590..2570513 - 924 WP_049003669.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49041.33 Da        Isoelectric Point: 8.6091

>T273045 WP_017900381.1 NZ_CP118278:c2565380-2564058 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLQAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT273045 WP_004205921.1 NZ_CP118278:c2565646-2565380 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246AZS4

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References