Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794633..795290 Replicon chromosome
Accession NZ_CP118278
Organism Klebsiella quasipneumoniae strain IIIF3SW-P1

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag HW458_RS03895 Protein ID WP_004205323.1
Coordinates 794880..795290 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HW458_RS03890 Protein ID WP_002916312.1
Coordinates 794633..794899 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW458_RS03865 (789784) 789784..791217 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
HW458_RS03870 (791336) 791336..792064 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
HW458_RS03875 (792114) 792114..792425 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
HW458_RS03880 (792588) 792588..793247 + 660 WP_004205319.1 hemolysin III family protein -
HW458_RS03885 (793404) 793404..794387 - 984 WP_205608766.1 tRNA-modifying protein YgfZ -
HW458_RS03890 (794633) 794633..794899 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HW458_RS03895 (794880) 794880..795290 + 411 WP_004205323.1 protein YgfX Toxin
HW458_RS03900 (795297) 795297..795818 - 522 WP_048325670.1 flavodoxin FldB -
HW458_RS03905 (795919) 795919..796815 + 897 WP_205608767.1 site-specific tyrosine recombinase XerD -
HW458_RS03910 (796838) 796838..797551 + 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HW458_RS03915 (797557) 797557..799290 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T273040 WP_004205323.1 NZ_CP118278:794880-795290 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT273040 WP_002916312.1 NZ_CP118278:794633-794899 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References