Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687886..4688399 Replicon chromosome
Accession NZ_CP118276
Organism Klebsiella quasipneumoniae strain F3-6P(2)

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HW455_RS22610 Protein ID WP_064190102.1
Coordinates 4687886..4688167 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HW455_RS22615 Protein ID WP_002886901.1
Coordinates 4688157..4688399 (-) Length 81 a.a.

Genomic Context


HW455_RS22595HW455_RS22600HW455_RS22605HW455_RS22610HW455_RS22615HW455_RS22620HW455_RS22625HW455_RS22630
Location: 4682928..4684583 (1656 bp)
Type: Others
Protein ID: WP_064178460.1
Location: 4684969..4687107 (2139 bp)
Type: Others
Protein ID: WP_004206513.1
Location: 4687418..4687882 (465 bp)
Type: Others
Protein ID: WP_064190101.1
Location: 4687886..4688167 (282 bp)
Type: Toxin
Protein ID: WP_064190102.1
Location: 4688157..4688399 (243 bp)
Type: Antitoxin
Protein ID: WP_002886901.1
Location: 4688477..4690387 (1911 bp)
Type: Others
Protein ID: WP_057212387.1
Location: 4690410..4691561 (1152 bp)
Type: Others
Protein ID: WP_065878155.1
Location: 4691628..4692368 (741 bp)
Type: Others
Protein ID: WP_004206507.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HW455_RS22595 (4682928)4682928..4684583+1656WP_064178460.1alpha,alpha-phosphotrehalase-
HW455_RS22600 (4684969)4684969..4687107+2139WP_004206513.1anaerobic ribonucleoside-triphosphate reductase-
HW455_RS22605 (4687418)4687418..4687882+465WP_064190101.1anaerobic ribonucleoside-triphosphate reductase-activating protein-
HW455_RS22610 (4687886)4687886..4688167-282WP_064190102.1type II toxin-antitoxin system RelE/ParE family toxinToxin
HW455_RS22615 (4688157)4688157..4688399-243WP_002886901.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
HW455_RS22620 (4688477)4688477..4690387-1911WP_057212387.1PRD domain-containing protein-
HW455_RS22625 (4690410)4690410..4691561-1152WP_065878155.1lactonase family protein-
HW455_RS22630 (4691628)4691628..4692368-741WP_004206507.1KDGP aldolase family protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.81 Da        Isoelectric Point: 10.1752

>T273030 WP_064190102.1 NZ_CP118276:c4688167-4687886 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp


Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273030 WP_002886901.1 NZ_CP118276:c4688399-4688157 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
No matching records found


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GLP0

References