Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687871..4688384 Replicon chromosome
Accession NZ_CP118275
Organism Klebsiella quasipneumoniae strain IF1SW-P4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HU252_RS22610 Protein ID WP_064190102.1
Coordinates 4687871..4688152 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HU252_RS22615 Protein ID WP_002886901.1
Coordinates 4688142..4688384 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU252_RS22595 (4682913) 4682913..4684568 + 1656 WP_064178460.1 alpha,alpha-phosphotrehalase -
HU252_RS22600 (4684954) 4684954..4687092 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
HU252_RS22605 (4687403) 4687403..4687867 + 465 WP_064190101.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HU252_RS22610 (4687871) 4687871..4688152 - 282 WP_064190102.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU252_RS22615 (4688142) 4688142..4688384 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HU252_RS22620 (4688462) 4688462..4690372 - 1911 WP_057212387.1 PRD domain-containing protein -
HU252_RS22625 (4690395) 4690395..4691546 - 1152 WP_065878155.1 lactonase family protein -
HU252_RS22630 (4691613) 4691613..4692353 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.81 Da        Isoelectric Point: 10.1752

>T273021 WP_064190102.1 NZ_CP118275:c4688152-4687871 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT273021 WP_002886901.1 NZ_CP118275:c4688384-4688142 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References