Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2583972..2585560 Replicon chromosome
Accession NZ_CP118273
Organism Klebsiella quasipneumoniae strain F3-6P(1)

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag HW457_RS12540 Protein ID WP_064187239.1
Coordinates 2583972..2585294 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag HW457_RS12545 Protein ID WP_004205921.1
Coordinates 2585294..2585560 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW457_RS12505 (2579054) 2579054..2579272 + 219 WP_002904808.1 ParD-like family protein -
HW457_RS12510 (2579253) 2579253..2580035 + 783 WP_065904745.1 type I methionyl aminopeptidase -
HW457_RS12515 (2580304) 2580304..2581419 + 1116 WP_065904746.1 serine hydrolase domain-containing protein -
HW457_RS12520 (2581406) 2581406..2581750 + 345 WP_004205915.1 hypothetical protein -
HW457_RS12525 (2581779) 2581779..2582312 + 534 WP_053810394.1 hypothetical protein -
HW457_RS12530 (2582315) 2582315..2582521 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
HW457_RS12535 (2582663) 2582663..2583955 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
HW457_RS12540 (2583972) 2583972..2585294 - 1323 WP_064187239.1 type II toxin-antitoxin system HipA family toxin Toxin
HW457_RS12545 (2585294) 2585294..2585560 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HW457_RS12550 (2585843) 2585843..2586169 - 327 WP_053810395.1 hydroxyisourate hydrolase -
HW457_RS12555 (2586166) 2586166..2586666 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HW457_RS12560 (2586644) 2586644..2588023 - 1380 WP_017900377.1 nucleobase:cation symporter-2 family protein -
HW457_RS12565 (2588369) 2588369..2589523 + 1155 WP_043519552.1 FAD-dependent urate hydroxylase HpxO -
HW457_RS12570 (2589504) 2589504..2590427 - 924 WP_004205929.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49026.36 Da        Isoelectric Point: 8.6091

>T273000 WP_064187239.1 NZ_CP118273:c2585294-2583972 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARRTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT273000 WP_004205921.1 NZ_CP118273:c2585560-2585294 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References