Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 802113..802770 Replicon chromosome
Accession NZ_CP118273
Organism Klebsiella quasipneumoniae strain F3-6P(1)

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag HW457_RS03930 Protein ID WP_004205323.1
Coordinates 802360..802770 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HW457_RS03925 Protein ID WP_002916312.1
Coordinates 802113..802379 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW457_RS03900 (797264) 797264..798697 - 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -
HW457_RS03905 (798816) 798816..799544 - 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
HW457_RS03910 (799594) 799594..799905 + 312 WP_004205318.1 N(4)-acetylcytidine aminohydrolase -
HW457_RS03915 (800068) 800068..800727 + 660 WP_004205319.1 hemolysin III family protein -
HW457_RS03920 (800884) 800884..801867 - 984 WP_049116109.1 tRNA-modifying protein YgfZ -
HW457_RS03925 (802113) 802113..802379 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HW457_RS03930 (802360) 802360..802770 + 411 WP_004205323.1 protein YgfX Toxin
HW457_RS03935 (802777) 802777..803298 - 522 WP_004205324.1 flavodoxin FldB -
HW457_RS03940 (803399) 803399..804295 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HW457_RS03945 (804318) 804318..805031 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HW457_RS03950 (805037) 805037..806770 + 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T272995 WP_004205323.1 NZ_CP118273:802360-802770 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT272995 WP_002916312.1 NZ_CP118273:802113-802379 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References