Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4687870..4688383 Replicon chromosome
Accession NZ_CP118271
Organism Klebsiella quasipneumoniae strain IF2SW-B3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HU253_RS22605 Protein ID WP_064190102.1
Coordinates 4687870..4688151 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HU253_RS22610 Protein ID WP_002886901.1
Coordinates 4688141..4688383 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU253_RS22590 (4682912) 4682912..4684567 + 1656 WP_064178460.1 alpha,alpha-phosphotrehalase -
HU253_RS22595 (4684953) 4684953..4687091 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
HU253_RS22600 (4687402) 4687402..4687866 + 465 WP_064190101.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HU253_RS22605 (4687870) 4687870..4688151 - 282 WP_064190102.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU253_RS22610 (4688141) 4688141..4688383 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HU253_RS22615 (4688461) 4688461..4690371 - 1911 WP_057212387.1 PRD domain-containing protein -
HU253_RS22620 (4690394) 4690394..4691545 - 1152 WP_065878155.1 lactonase family protein -
HU253_RS22625 (4691612) 4691612..4692352 - 741 WP_004206507.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(18-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11031.81 Da        Isoelectric Point: 10.1752

>T272985 WP_064190102.1 NZ_CP118271:c4688151-4687870 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNNLQQIMQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT272985 WP_002886901.1 NZ_CP118271:c4688383-4688141 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References