Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4617670..4618453 | Replicon | chromosome |
| Accession | NZ_CP118271 | ||
| Organism | Klebsiella quasipneumoniae strain IF2SW-B3 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | HU253_RS22300 | Protein ID | WP_069734344.1 |
| Coordinates | 4617670..4618044 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | HU253_RS22305 | Protein ID | WP_069734343.1 |
| Coordinates | 4618094..4618453 (-) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HU253_RS22285 (4614006) | 4614006..4614440 | + | 435 | WP_069734348.1 | antiviral protein Drt1b | - |
| HU253_RS22290 (4614741) | 4614741..4615538 | - | 798 | WP_117088841.1 | helix-turn-helix transcriptional regulator | - |
| HU253_RS22295 (4616142) | 4616142..4617131 | + | 990 | WP_069734346.1 | glycosyltransferase | - |
| HU253_RS22300 (4617670) | 4617670..4618044 | - | 375 | WP_069734344.1 | TA system toxin CbtA family protein | Toxin |
| HU253_RS22305 (4618094) | 4618094..4618453 | - | 360 | WP_069734343.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HU253_RS22310 (4618476) | 4618476..4618697 | - | 222 | WP_069734358.1 | DUF987 domain-containing protein | - |
| HU253_RS22315 (4618711) | 4618711..4619193 | - | 483 | WP_069734342.1 | DNA repair protein RadC | - |
| HU253_RS22320 (4619434) | 4619434..4619913 | - | 480 | WP_069734341.1 | antirestriction protein | - |
| HU253_RS22325 (4619993) | 4619993..4620814 | - | 822 | WP_069734340.1 | DUF932 domain-containing protein | - |
| HU253_RS22330 (4620925) | 4620925..4621137 | - | 213 | WP_010434180.1 | hypothetical protein | - |
| HU253_RS22335 (4621218) | 4621218..4621577 | - | 360 | WP_069734339.1 | hypothetical protein | - |
| HU253_RS22340 (4621632) | 4621632..4622042 | - | 411 | WP_069734357.1 | hypothetical protein | - |
| HU253_RS22345 (4622150) | 4622150..4622827 | - | 678 | WP_069734338.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4614228..4639875 | 25647 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13963.97 Da Isoelectric Point: 10.1569
>T272984 WP_069734344.1 NZ_CP118271:c4618044-4617670 [Klebsiella quasipneumoniae]
MQKQSLSSHRAASSRLSSIEIWRKLLKYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGDRFSGGK
MQKQSLSSHRAASSRLSSIEIWRKLLKYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGDRFSGGK
Download Length: 375 bp
Antitoxin
Download Length: 120 a.a. Molecular weight: 13362.56 Da Isoelectric Point: 8.5076
>AT272984 WP_069734343.1 NZ_CP118271:c4618453-4618094 [Klebsiella quasipneumoniae]
MKKATRVINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLASRELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSATTA
MKKATRVINHNIAEPWWGLRRNITPCLGARLVQEGNRLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLASRELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPTSATTA
Download Length: 360 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|