Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2053756..2055317 Replicon chromosome
Accession NZ_CP118269
Organism Pantoea sp. Lij88

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PU624_RS13330 Protein ID WP_283545369.1
Coordinates 2054004..2055317 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PU624_RS13325 Protein ID WP_283545368.1
Coordinates 2053756..2054004 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU624_RS13305 (PU624_13305) 2049142..2051367 + 2226 WP_283545365.1 iron ABC transporter permease -
PU624_RS13310 (PU624_13310) 2051364..2052425 + 1062 WP_283545366.1 ABC transporter ATP-binding protein -
PU624_RS13315 (PU624_13315) 2052449..2053240 + 792 WP_283545367.1 inositol monophosphatase family protein -
PU624_RS13320 (PU624_13320) 2053270..2053579 - 310 Protein_1842 N-acetyltransferase -
PU624_RS13325 (PU624_13325) 2053756..2054004 + 249 WP_283545368.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PU624_RS13330 (PU624_13330) 2054004..2055317 + 1314 WP_283545369.1 type II toxin-antitoxin system HipA family toxin Toxin
PU624_RS13335 (PU624_13335) 2055412..2055618 + 207 WP_283545370.1 type II toxin-antitoxin system MqsA family antitoxin -
PU624_RS13340 (PU624_13340) 2055906..2057279 + 1374 WP_283545371.1 M24 family metallopeptidase -
PU624_RS13345 (PU624_13345) 2057394..2059439 + 2046 WP_283545372.1 FUSC family protein -
PU624_RS13350 (PU624_13350) 2059777..2060118 - 342 WP_283545373.1 gamma-glutamylcyclotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49057.68 Da        Isoelectric Point: 8.8536

>T272971 WP_283545369.1 NZ_CP118269:2054004-2055317 [Pantoea sp. Lij88]
MKRLVAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARFEVLDEARLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTEEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGKMRALAVERFDRRW
SRDKSRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSKAIEDRYRFMLFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKQVSFDRDSLQQIFDFFINAFP
QAVVSVRDALPADFPQHIADAIFSHSLIMLERLRHTE

Download         Length: 1314 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9258.56 Da        Isoelectric Point: 5.6663

>AT272971 WP_283545368.1 NZ_CP118269:2053756-2054004 [Pantoea sp. Lij88]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLDVQEKEEVTAPPVHGED
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References