Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 5025444..5025973 Replicon chromosome
Accession NZ_CP118233
Organism Micromonospora chalcea strain 1K05785M01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PVK74_RS22480 Protein ID WP_184681101.1
Coordinates 5025444..5025701 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag PVK74_RS22485 Protein ID WP_274477148.1
Coordinates 5025698..5025973 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK74_RS22455 (PVK74_22455) 5021057..5021485 + 429 WP_274477146.1 helix-turn-helix domain-containing protein -
PVK74_RS22460 (PVK74_22460) 5021764..5023248 + 1485 WP_209959620.1 endo-1,4-beta-xylanase -
PVK74_RS22465 (PVK74_22465) 5023332..5023850 - 519 WP_113972234.1 cupin domain-containing protein -
PVK74_RS22470 (PVK74_22470) 5023944..5024681 - 738 WP_051611289.1 class I SAM-dependent methyltransferase -
PVK74_RS22475 (PVK74_22475) 5024947..5025279 - 333 WP_274477147.1 hypothetical protein -
PVK74_RS22480 (PVK74_22480) 5025444..5025701 - 258 WP_184681101.1 Txe/YoeB family addiction module toxin Toxin
PVK74_RS22485 (PVK74_22485) 5025698..5025973 - 276 WP_274477148.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PVK74_RS22490 (PVK74_22490) 5026257..5026430 - 174 WP_167435514.1 hypothetical protein -
PVK74_RS22495 (PVK74_22495) 5026427..5026645 - 219 WP_069088171.1 flavin reductase -
PVK74_RS22500 (PVK74_22500) 5027018..5027419 + 402 WP_274477149.1 winged helix-turn-helix domain-containing protein -
PVK74_RS22505 (PVK74_22505) 5028056..5028790 + 735 WP_274477150.1 hypothetical protein -
PVK74_RS22510 (PVK74_22510) 5028804..5028899 + 96 Protein_4459 hypothetical protein -
PVK74_RS22515 (PVK74_22515) 5029135..5029629 - 495 WP_151010518.1 toll/interleukin-1 receptor domain-containing protein -
PVK74_RS22520 (PVK74_22520) 5030234..5030608 - 375 WP_274477151.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5024947..5035386 10439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10150.58 Da        Isoelectric Point: 9.7992

>T272964 WP_184681101.1 NZ_CP118233:c5025701-5025444 [Micromonospora chalcea]
VRLVFTATAWNQYLSHTDRKLVKRINDLITDVMRNGYEGIGKPEPLRGELSGFWSRRIDREHRLVYRITKDDVEIIACRY
HYGDR

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10047.26 Da        Isoelectric Point: 4.2070

>AT272964 WP_274477148.1 NZ_CP118233:c5025973-5025698 [Micromonospora chalcea]
MRTVNFTQLRQNLAAELDSVINDAEEVVVTRSGHEPVVIVPLAEYEAMKETEYLLRNPANAAALRRSIAELEQGDAAERD
LVDPATVRDVA

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References