Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3764236..3764885 Replicon chromosome
Accession NZ_CP118227
Organism Proteus mirabilis strain CY32

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag PU712_RS17635 Protein ID WP_012368534.1
Coordinates 3764236..3764655 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag PU712_RS17640 Protein ID WP_012368535.1
Coordinates 3764652..3764885 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU712_RS17605 (PU712_17605) 3759514..3760392 - 879 WP_004246812.1 23S rRNA pseudouridine(2604) synthase RluF -
PU712_RS17610 (PU712_17610) 3760568..3761482 - 915 WP_004246811.1 fatty acid biosynthesis protein FabY -
PU712_RS17615 (PU712_17615) 3761506..3761943 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
PU712_RS17620 (PU712_17620) 3762024..3762641 - 618 WP_020946398.1 glucose-1-phosphatase -
PU712_RS17625 (PU712_17625) 3763294..3763710 - 417 WP_046334846.1 hypothetical protein -
PU712_RS17630 (PU712_17630) 3763688..3763966 - 279 WP_230629709.1 hypothetical protein -
PU712_RS17635 (PU712_17635) 3764236..3764655 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
PU712_RS17640 (PU712_17640) 3764652..3764885 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PU712_RS17645 (PU712_17645) 3766176..3766376 + 201 WP_104836792.1 hypothetical protein -
PU712_RS17650 (PU712_17650) 3766634..3767584 - 951 WP_104836793.1 reverse transcriptase family protein -
PU712_RS17655 (PU712_17655) 3767577..3767723 - 147 WP_158660334.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T272960 WP_012368534.1 NZ_CP118227:c3764655-3764236 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT272960 WP_012368535.1 NZ_CP118227:c3764885-3764652 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References