Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 84448..86046 Replicon chromosome
Accession NZ_CP118227
Organism Proteus mirabilis strain CY32

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PU712_RS00420 Protein ID WP_063108770.1
Coordinates 84448..85791 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PU712_RS00425 Protein ID WP_172767614.1
Coordinates 85795..86046 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU712_RS00400 (PU712_00400) 80065..81249 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
PU712_RS00405 (PU712_00405) 81359..82891 - 1533 WP_004246422.1 glycerol kinase GlpK -
PU712_RS00410 (PU712_00410) 82934..83749 - 816 WP_004246421.1 MIP/aquaporin family protein -
PU712_RS00415 (PU712_00415) 84046..84288 + 243 WP_012368679.1 cell division protein ZapB -
PU712_RS00420 (PU712_00420) 84448..85791 - 1344 WP_063108770.1 type II toxin-antitoxin system HipA family toxin Toxin
PU712_RS00425 (PU712_00425) 85795..86046 - 252 WP_172767614.1 helix-turn-helix domain-containing protein Antitoxin
PU712_RS00430 (PU712_00430) 86287..86552 + 266 Protein_85 IS4 family transposase -
PU712_RS00435 (PU712_00435) 86622..87140 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
PU712_RS00440 (PU712_00440) 87249..88166 - 918 WP_020946557.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
PU712_RS00445 (PU712_00445) 88265..89605 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
PU712_RS00450 (PU712_00450) 89618..90148 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(150-399)

Antitoxin

(13-63)


Sequences


Toxin        


Download         Length: 448 a.a.        Molecular weight: 49787.20 Da        Isoelectric Point: 5.3203

>T272956 WP_063108770.1 NZ_CP118227:c85791-84448 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN

Download         Length: 1344 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.76 Da        Isoelectric Point: 8.7284

>AT272956 WP_172767614.1 NZ_CP118227:c86046-85795 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGTNLSEGKVWN
KEW

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References