Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 84448..86046 | Replicon | chromosome |
Accession | NZ_CP118227 | ||
Organism | Proteus mirabilis strain CY32 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | - |
Locus tag | PU712_RS00420 | Protein ID | WP_063108770.1 |
Coordinates | 84448..85791 (-) | Length | 448 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | PU712_RS00425 | Protein ID | WP_172767614.1 |
Coordinates | 85795..86046 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PU712_RS00400 (PU712_00400) | 80065..81249 | + | 1185 | WP_004246423.1 | multidrug efflux MFS transporter EmrD | - |
PU712_RS00405 (PU712_00405) | 81359..82891 | - | 1533 | WP_004246422.1 | glycerol kinase GlpK | - |
PU712_RS00410 (PU712_00410) | 82934..83749 | - | 816 | WP_004246421.1 | MIP/aquaporin family protein | - |
PU712_RS00415 (PU712_00415) | 84046..84288 | + | 243 | WP_012368679.1 | cell division protein ZapB | - |
PU712_RS00420 (PU712_00420) | 84448..85791 | - | 1344 | WP_063108770.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
PU712_RS00425 (PU712_00425) | 85795..86046 | - | 252 | WP_172767614.1 | helix-turn-helix domain-containing protein | Antitoxin |
PU712_RS00430 (PU712_00430) | 86287..86552 | + | 266 | Protein_85 | IS4 family transposase | - |
PU712_RS00435 (PU712_00435) | 86622..87140 | - | 519 | WP_004246419.1 | ribonuclease E activity regulator RraA | - |
PU712_RS00440 (PU712_00440) | 87249..88166 | - | 918 | WP_020946557.1 | 1,4-dihydroxy-2-naphthoate polyprenyltransferase | - |
PU712_RS00445 (PU712_00445) | 88265..89605 | - | 1341 | WP_004246417.1 | HslU--HslV peptidase ATPase subunit | - |
PU712_RS00450 (PU712_00450) | 89618..90148 | - | 531 | WP_004246416.1 | ATP-dependent protease subunit HslV | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 448 a.a. Molecular weight: 49787.20 Da Isoelectric Point: 5.3203
>T272956 WP_063108770.1 NZ_CP118227:c85791-84448 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRWSSGTSSQNMMVSN
Download Length: 1344 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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