Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 14602..15203 Replicon chromosome
Accession NZ_CP118227
Organism Proteus mirabilis strain CY32

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PU712_RS00065 Protein ID WP_172767598.1
Coordinates 14602..14985 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag PU712_RS00070 Protein ID WP_004246496.1
Coordinates 14982..15203 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU712_RS00040 (PU712_00040) 9975..10433 + 459 WP_004249766.1 GNAT family N-acetyltransferase -
PU712_RS00045 (PU712_00045) 10529..11266 - 738 WP_004249950.1 tetratricopeptide repeat protein -
PU712_RS00050 (PU712_00050) 11375..12274 + 900 WP_063108742.1 N-acetylmuramic acid 6-phosphate etherase -
PU712_RS00055 (PU712_00055) 12631..13869 - 1239 WP_020946511.1 HipA domain-containing protein -
PU712_RS00060 (PU712_00060) 13882..14196 - 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
PU712_RS00065 (PU712_00065) 14602..14985 - 384 WP_172767598.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PU712_RS00070 (PU712_00070) 14982..15203 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PU712_RS00075 (PU712_00075) 15484..16347 - 864 WP_004249947.1 YicC/YloC family endoribonuclease -
PU712_RS00080 (PU712_00080) 16474..17190 + 717 WP_004249760.1 ribonuclease PH -
PU712_RS00085 (PU712_00085) 17272..17916 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
PU712_RS00090 (PU712_00090) 18235..18840 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
PU712_RS00095 (PU712_00095) 18960..19418 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(3-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14499.58 Da        Isoelectric Point: 8.5125

>T272955 WP_172767598.1 NZ_CP118227:c14985-14602 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVVGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT272955 WP_004246496.1 NZ_CP118227:c15203-14982 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References