Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5699978..5700588 Replicon chromosome
Accession NZ_CP118223
Organism Klebsiella grimontii strain YWC001

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PVK07_RS26790 Protein ID WP_098363641.1
Coordinates 5699978..5700352 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PVK07_RS26795 Protein ID WP_077265771.1
Coordinates 5700349..5700588 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK07_RS26775 (PVK07_26775) 5697133..5698035 + 903 WP_201160658.1 formate dehydrogenase subunit beta -
PVK07_RS26780 (PVK07_26780) 5698032..5698667 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
PVK07_RS26785 (PVK07_26785) 5699011..5699940 + 930 WP_131931038.1 formate dehydrogenase accessory protein FdhE -
PVK07_RS26790 (PVK07_26790) 5699978..5700352 - 375 WP_098363641.1 type II toxin-antitoxin system VapC family toxin Toxin
PVK07_RS26795 (PVK07_26795) 5700349..5700588 - 240 WP_077265771.1 CopG family transcriptional regulator Antitoxin
PVK07_RS26800 (PVK07_26800) 5700794..5701711 + 918 WP_024360706.1 alpha/beta hydrolase -
PVK07_RS26805 (PVK07_26805) 5701729..5702670 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
PVK07_RS26810 (PVK07_26810) 5702715..5703152 - 438 WP_004132870.1 D-aminoacyl-tRNA deacylase -
PVK07_RS26815 (PVK07_26815) 5703149..5704009 - 861 WP_004127107.1 virulence factor BrkB family protein -
PVK07_RS26820 (PVK07_26820) 5704003..5704602 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14081.36 Da        Isoelectric Point: 8.4571

>T272954 WP_098363641.1 NZ_CP118223:c5700352-5699978 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWTEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9307.51 Da        Isoelectric Point: 4.3253

>AT272954 WP_077265771.1 NZ_CP118223:c5700588-5700349 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEEGVEFERKLREEWQ

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References