Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846407..847064 Replicon chromosome
Accession NZ_CP118223
Organism Klebsiella grimontii strain YWC001

Toxin (Protein)


Gene name cptA Uniprot ID A0A9E1DA00
Locus tag PVK07_RS04110 Protein ID WP_024358614.1
Coordinates 846654..847064 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag PVK07_RS04105 Protein ID WP_004124953.1
Coordinates 846407..846673 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK07_RS04090 (PVK07_04090) 841659..842084 - 426 WP_024358617.1 PTS sugar transporter subunit IIA -
PVK07_RS04095 (PVK07_04095) 842205..845003 - 2799 WP_024358616.1 transcriptional regulator DagR -
PVK07_RS04100 (PVK07_04100) 845179..846162 - 984 WP_024358615.1 tRNA-modifying protein YgfZ -
PVK07_RS04105 (PVK07_04105) 846407..846673 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
PVK07_RS04110 (PVK07_04110) 846654..847064 + 411 WP_024358614.1 protein YgfX Toxin
PVK07_RS04115 (PVK07_04115) 847073..847594 - 522 WP_024358613.1 flavodoxin FldB -
PVK07_RS04120 (PVK07_04120) 847716..848612 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
PVK07_RS04125 (PVK07_04125) 848635..849348 + 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PVK07_RS04130 (PVK07_04130) 849354..851087 + 1734 WP_131930459.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16135.97 Da        Isoelectric Point: 10.9455

>T272945 WP_024358614.1 NZ_CP118223:846654-847064 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWEIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT272945 WP_004124953.1 NZ_CP118223:846407-846673 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References