Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 760747..762445 Replicon chromosome
Accession NZ_CP118223
Organism Klebsiella grimontii strain YWC001

Toxin (Protein)


Gene name mosT Uniprot ID -
Locus tag PVK07_RS03670 Protein ID WP_148866082.1
Coordinates 760747..761676 (-) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag PVK07_RS03675 Protein ID WP_177911274.1
Coordinates 761663..762445 (-) Length 261 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK07_RS03650 (PVK07_03650) 755983..757353 - 1371 WP_049089071.1 cystathionine beta-synthase -
PVK07_RS03655 (PVK07_03655) 757899..759287 + 1389 WP_049085001.1 DASS family sodium-coupled anion symporter -
PVK07_RS03660 (PVK07_03660) 759671..759964 + 294 WP_049101739.1 DUF1778 domain-containing protein -
PVK07_RS03665 (PVK07_03665) 759961..760449 + 489 WP_148866084.1 GNAT family N-acetyltransferase -
PVK07_RS03670 (PVK07_03670) 760747..761676 - 930 WP_148866082.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PVK07_RS03675 (PVK07_03675) 761663..762445 - 783 WP_177911274.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
PVK07_RS03680 (PVK07_03680) 762768..763739 + 972 WP_148866080.1 DUF4747 family protein -
PVK07_RS03685 (PVK07_03685) 763769..764326 + 558 WP_148866078.1 hypothetical protein -
PVK07_RS03690 (PVK07_03690) 764391..764552 - 162 Protein_725 helix-turn-helix transcriptional regulator -
PVK07_RS03695 (PVK07_03695) 764896..765357 + 462 WP_148866076.1 hypothetical protein -
PVK07_RS03700 (PVK07_03700) 765390..765581 + 192 WP_224250691.1 helix-turn-helix transcriptional regulator -
PVK07_RS03705 (PVK07_03705) 766439..767326 + 888 WP_148866070.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-274)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(3-90)


Sequences

Toxin        


Download         Length: 310 a.a.        Molecular weight: 34828.27 Da        Isoelectric Point: 7.3224

>T272944 WP_148866082.1 NZ_CP118223:c761676-760747 [Klebsiella grimontii]
MDLRDSYARQVRLLMTALPHVAKEPCFALKGGTAINLFVQDFPRLSVDIDLAYKNFADRETDLAAINDALIRITESLNGR
PGITAIRQENKADEKRIIVSTADAKIKIEVSPVWRGLLLPPAEMPVCEQVEMEYGFTTINVVSLADLYGGKICAALDRQH
PRDLFDVLNMLAKPGLTREIFDGFLCYLAGHPRPIAELLAPNWDTARIATLYAQEFSGMTQQETSLGSLLSVTTLLPQAL
KSHLTDRDRQFLLGYKQNTPDWSLYRYPEIQHLPAIRWKLRNLALLKDKNPAKYAAAVNKLEGVLERYF

Download         Length: 930 bp

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29276.52 Da        Isoelectric Point: 8.1293

>AT272944 WP_177911274.1 NZ_CP118223:c762445-761663 [Klebsiella grimontii]
MPNYLNWLMQHTLPGQVLLQSWLTRNGIDRKLSYLYVQSGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKQQIWLALPAYVKLPGWFVAFEQSATFVTLYTSGLTVDIAPFTTKLNIGDRQLTGSASELAAYEIA
CGVPSLISFEHADALFQGMNLLSPRKLQTLLCASHSVKTNRVMLYLARRNEHPYFQYLDQSGIETGTGKRQIVPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References