272943

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 759671..760449 Replicon chromosome
Accession NZ_CP118223
Organism Klebsiella grimontii strain YWC001

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag PVK07_RS03665 Protein ID WP_148866084.1
Coordinates 759961..760449 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A2J5Q8I3
Locus tag PVK07_RS03660 Protein ID WP_049101739.1
Coordinates 759671..759964 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PVK07_RS03645 (PVK07_03645) 754827..755972 - 1146 WP_014839554.1 PLP-dependent aspartate aminotransferase family protein -
PVK07_RS03650 (PVK07_03650) 755983..757353 - 1371 WP_049089071.1 cystathionine beta-synthase -
PVK07_RS03655 (PVK07_03655) 757899..759287 + 1389 WP_049085001.1 DASS family sodium-coupled anion symporter -
PVK07_RS03660 (PVK07_03660) 759671..759964 + 294 WP_049101739.1 DUF1778 domain-containing protein Antitoxin
PVK07_RS03665 (PVK07_03665) 759961..760449 + 489 WP_148866084.1 GNAT family N-acetyltransferase Toxin
PVK07_RS03670 (PVK07_03670) 760747..761676 - 930 WP_148866082.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
PVK07_RS03675 (PVK07_03675) 761663..762445 - 783 WP_177911274.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
PVK07_RS03680 (PVK07_03680) 762768..763739 + 972 WP_148866080.1 DUF4747 family protein -
PVK07_RS03685 (PVK07_03685) 763769..764326 + 558 WP_148866078.1 hypothetical protein -
PVK07_RS03690 (PVK07_03690) 764391..764552 - 162 Protein_725 helix-turn-helix transcriptional regulator -
PVK07_RS03695 (PVK07_03695) 764896..765357 + 462 WP_148866076.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17510.49 Da        Isoelectric Point: 7.7529

>T272943 WP_148866084.1 NZ_CP118223:759961-760449 [Klebsiella grimontii]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCDDAKVMAYYSLASSAVATNTAPGHFRRNMPDPI
PVVVLGRLAVDKSLHGKGLGRALIRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMLMVTLGDLVG
SV

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10902.55 Da        Isoelectric Point: 9.8590

>AT272943 WP_049101739.1 NZ_CP118223:759671-759964 [Klebsiella grimontii]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5Q8I3

References