Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 359411..360882 Replicon chromosome
Accession NZ_CP118166
Organism Hyphococcus flavus strain MCCC 1K03223

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PUV54_RS01845 Protein ID WP_274493814.1
Coordinates 359411..360670 (-) Length 420 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PUV54_RS01850 Protein ID WP_274493815.1
Coordinates 360667..360882 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV54_RS01815 (PUV54_01815) 354433..354879 + 447 WP_274493808.1 hypothetical protein -
PUV54_RS01820 (PUV54_01820) 354979..355635 + 657 WP_274493809.1 hypothetical protein -
PUV54_RS01825 (PUV54_01825) 355716..356666 + 951 WP_274493810.1 tetratricopeptide repeat protein -
PUV54_RS01830 (PUV54_01830) 356692..358308 + 1617 WP_274493811.1 tetratricopeptide repeat protein -
PUV54_RS01835 (PUV54_01835) 358337..359056 + 720 WP_274493812.1 hypothetical protein -
PUV54_RS01840 (PUV54_01840) 359180..359377 + 198 WP_274493813.1 hypothetical protein -
PUV54_RS01845 (PUV54_01845) 359411..360670 - 1260 WP_274493814.1 type II toxin-antitoxin system HipA family toxin Toxin
PUV54_RS01850 (PUV54_01850) 360667..360882 - 216 WP_274493815.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
PUV54_RS01855 (PUV54_01855) 361317..362174 - 858 WP_274493816.1 4,5-DOPA dioxygenase extradiol -
PUV54_RS01860 (PUV54_01860) 362225..362791 - 567 WP_274493817.1 NAD(P)H-dependent oxidoreductase -
PUV54_RS01865 (PUV54_01865) 362838..363233 - 396 WP_274493818.1 DoxX family protein -
PUV54_RS01870 (PUV54_01870) 363332..364237 - 906 WP_274493819.1 LysR family transcriptional regulator -
PUV54_RS01875 (PUV54_01875) 364537..365166 + 630 WP_274493820.1 trimeric intracellular cation channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 272022..386020 113998


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-379)

Antitoxin

Cro/C1-type helix-turn-helix domain

(7-62)


Sequences

Toxin        


Download         Length: 420 a.a.        Molecular weight: 46141.65 Da        Isoelectric Point: 5.0653

>T272924 WP_274493814.1 NZ_CP118166:c360670-359411 [Hyphococcus flavus]
MTKTLKVWWGGEIVGALTIDQHGEMGFSYASDWLADPEKPALSFSLPKREEPFNRRECRPFFEGLLPEESQRFAVSRALG
VSHGNEFKLLNELGGEVAGALTLWPEGEEPPAPSLATQNKPLGEAALVDLLDELPSRPFLAGREGFRLSLAGAQSKIPVI
LVDGEIALPAPGEATSHILKPPIERFPGTTENEAFAMRLAIKIGLDAANVEIRRAGERSFLLVARYDRIRGDDGALQRLH
QEDFCQALGFTSDRKYAADGGPVFRDCFDLLRRAATRPAVEVLKLFDAAIYNLIIGNADAHAKNFSLLYRKNGAIELAPL
YDLLSTAYYPELSPRLAMKIAKRHTLEELKPSDWEKFADETGLALRFIRTRAKELANAVIESIGKTNSEILESASDGDAV
QEIADLISMRASSLCQRIP

Download         Length: 1260 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7484.79 Da        Isoelectric Point: 10.3943

>AT272924 WP_274493815.1 NZ_CP118166:c360882-360667 [Hyphococcus flavus]
MTPKKIGLKIRELRKRQGLRQDQLAGAAGVGLRFLIELEAGKETAQLGKTLAVLNALGCKIELADPGGDGS

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References