Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1968013..1969562 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PUV55_RS09860 Protein ID WP_274358731.1
Coordinates 1968246..1969562 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A836YYU2
Locus tag PUV55_RS09855 Protein ID WP_005713287.1
Coordinates 1968013..1968252 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS09835 (PUV55_09835) 1963582..1963992 - 411 WP_112062755.1 preprotein translocase subunit SecE -
PUV55_RS09840 (PUV55_09840) 1964178..1965275 + 1098 WP_035498491.1 ISAs1 family transposase -
PUV55_RS09845 (PUV55_09845) 1965462..1966907 - 1446 WP_274358725.1 metalloprotease TldD -
PUV55_RS09850 (PUV55_09850) 1967038..1967865 + 828 WP_035493932.1 alpha/beta hydrolase-fold protein -
PUV55_RS09855 (PUV55_09855) 1968013..1968252 + 240 WP_005713287.1 XRE family transcriptional regulator Antitoxin
PUV55_RS09860 (PUV55_09860) 1968246..1969562 + 1317 WP_274358731.1 type II toxin-antitoxin system HipA family toxin Toxin
PUV55_RS09865 (PUV55_09865) 1969566..1971107 - 1542 WP_274358733.1 PLP-dependent aminotransferase family protein -
PUV55_RS09870 (PUV55_09870) 1971131..1971502 - 372 WP_020457622.1 LysR substrate-binding domain-containing protein -
PUV55_RS09875 (PUV55_09875) 1971546..1971905 + 360 WP_010787368.1 hypothetical protein -
PUV55_RS09880 (PUV55_09880) 1972092..1972665 + 574 Protein_1919 RhuM family protein -
PUV55_RS09885 (PUV55_09885) 1972737..1972862 - 126 WP_020457624.1 LysR family transcriptional regulator -
PUV55_RS09890 (PUV55_09890) 1972997..1973440 + 444 WP_005713602.1 nuclear transport factor 2 family protein -
PUV55_RS09895 (PUV55_09895) 1973440..1973697 + 258 WP_035491916.1 hypothetical protein -
PUV55_RS09900 (PUV55_09900) 1973884..1974471 - 588 WP_021119019.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 50004.22 Da        Isoelectric Point: 7.3465

>T272922 WP_274358731.1 NZ_CP118165:1968246-1969562 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFSYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELDESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTSIMKQVQKVSMK

Download         Length: 1317 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9068.48 Da        Isoelectric Point: 9.7687

>AT272922 WP_005713287.1 NZ_CP118165:1968013-1968252 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIHPRPEKTEGNDEW

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A836YYU2

References