Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1373699..1375386 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PUV55_RS06740 Protein ID WP_274358610.1
Coordinates 1374043..1375386 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PUV55_RS06735 Protein ID WP_223300026.1
Coordinates 1373699..1374061 (-) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS06715 (PUV55_06715) 1369767..1370717 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
PUV55_RS06720 (PUV55_06720) 1370745..1371590 - 846 WP_005713151.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PUV55_RS06725 (PUV55_06725) 1371592..1372224 - 633 WP_005713149.1 lipoprotein insertase outer membrane protein LolB -
PUV55_RS06730 (PUV55_06730) 1372345..1373670 - 1326 WP_261490723.1 ATP-dependent RNA helicase SrmB -
PUV55_RS06735 (PUV55_06735) 1373699..1374061 - 363 WP_223300026.1 helix-turn-helix transcriptional regulator Antitoxin
PUV55_RS06740 (PUV55_06740) 1374043..1375386 - 1344 WP_274358610.1 HipA domain-containing protein Toxin
PUV55_RS06745 (PUV55_06745) 1375500..1375937 - 438 WP_021110342.1 ribosomal protein S18-alanine N-acetyltransferase -
PUV55_RS06750 (PUV55_06750) 1376179..1376619 - 441 WP_016528419.1 M23 family metallopeptidase -
PUV55_RS06755 (PUV55_06755) 1376621..1377034 - 414 WP_005713136.1 DNA polymerase III subunit psi -
PUV55_RS06760 (PUV55_06760) 1377117..1378058 + 942 WP_160428987.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
PUV55_RS06765 (PUV55_06765) 1378208..1380385 + 2178 WP_078208434.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-98)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51130.15 Da        Isoelectric Point: 5.2205

>T272921 WP_274358610.1 NZ_CP118165:c1375386-1374043 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATRQVWIDNLQQGASSDDFYLVKFPRGKRSVIDCDILRTEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13880.42 Da        Isoelectric Point: 10.2782

>AT272921 WP_223300026.1 NZ_CP118165:c1374061-1373699 [Glaesserella parasuis]
MAIIIIMEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLEN
DKGNYSIDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References