Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 973655..974190 Replicon chromosome
Accession NZ_CP118165
Organism Glaesserella parasuis strain XP11

Toxin (Protein)


Gene name relE Uniprot ID A0A836YZW4
Locus tag PUV55_RS04745 Protein ID WP_016528228.1
Coordinates 973655..973939 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag PUV55_RS04750 Protein ID WP_010785924.1
Coordinates 973936..974190 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUV55_RS04725 (PUV55_04725) 969286..969777 + 492 WP_160420853.1 acetolactate synthase small subunit -
PUV55_RS04730 (PUV55_04730) 969884..970705 - 822 WP_274360138.1 PHP domain-containing protein -
PUV55_RS04735 (PUV55_04735) 970854..971813 - 960 WP_016528226.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
PUV55_RS04740 (PUV55_04740) 971896..973446 - 1551 WP_016528227.1 exodeoxyribonuclease I -
PUV55_RS04745 (PUV55_04745) 973655..973939 - 285 WP_016528228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUV55_RS04750 (PUV55_04750) 973936..974190 - 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
PUV55_RS04755 (PUV55_04755) 974307..975062 - 756 WP_010785925.1 ABC transporter permease -
PUV55_RS04760 (PUV55_04760) 975084..975980 - 897 WP_044009101.1 ABC transporter ATP-binding protein -
PUV55_RS04765 (PUV55_04765) 975986..978004 - 2019 WP_005712693.1 DNA polymerase III subunit gamma/tau -
PUV55_RS04770 (PUV55_04770) 978092..978634 - 543 WP_005712695.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11276.27 Da        Isoelectric Point: 10.5362

>T272919 WP_016528228.1 NZ_CP118165:c973939-973655 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
RERNDVYQKVQLRL

Download         Length: 285 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT272919 WP_010785924.1 NZ_CP118165:c974190-973936 [Glaesserella parasuis]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZW4

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References